This module contains 10 genes including PRKG1, SYT1, NFIA, ITPR2, and BNC2, with top enrichment in cAMP-dependent protein kinase activity and calcium ion binding. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN, GSC, and FOXA2 repress it. The module's regulatory profile suggests involvement in second-messenger signaling during endoderm specification.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.