DE-9 ›

DE-9.5

Submodule 14 genes

Cell adhesion and axon guidance signaling

This module contains 14 genes including CADM1, SLIT2, ETV1, VAV3, and GRIK2, enriched for cell adhesion molecules and axon guidance pathways. Knockdown of SOX17 activates this module. Knockdown of CNBP represses this module.

Key terms: myelin assembly detection of cold stimulus involved in thermoception negative regulation of neutrophil migration negative regulation of axon guidance Notable genes: CADM1 SLIT2 ETV1 GRIK2 VAV3 EPB41L3 CDK14 NRG3 Top TFs: CNBP SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (14)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

| |
Low
High z
Huangfu Lab · Publications · Resources · Contact