This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:64,444,744–64,445,851 | 241.2 kb | Distal (>10kb) Multiome | 328 | |
| chr3:64,489,031–64,490,029 | 197.1 kb | Distal (>10kb) Multiome | 232 | |
| chr3:64,649,591–64,650,867 | 36.4 kb | Distal (>10kb) Multiome | 252 | |
| chr3:64,676,859–64,677,175 | 9.4 kb | Proximal (<10kb) | 31 | |
| chr3:64,684,758–64,686,900 | 576 bp | At TSS Multiome | 510 | |
| chr3:64,687,325–64,689,155 | 1.4 kb | Proximal (<10kb) Multiome | 398 | |
| chr3:65,368,876–65,369,448 | 682.5 kb | Distal (>10kb) Multiome HiCAR | 51 |
Genomic view of the ADAMTS9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.