This gene encodes a member of the synaptotagmin protein family. The synaptotagmins are integral membrane proteins of synaptic vesicles that serve as calcium sensors in the process of vesicular trafficking and exocytosis. The encoded protein participates in triggering neurotransmitter release at the synapse in response to calcium binding. Mutations in this gene are associated with Baker-Gordon syndrome. [provided by RefSeq, Jan 2023]
Transcription factors with Perturb-seq knockdown data for SYT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:78,651,760–78,652,536 | 212.7 kb | Distal (>10kb) Multiome | 190 | |
| chr12:78,680,386–78,681,515 | 183.9 kb | Distal (>10kb) Multiome | 112 | |
| chr12:78,731,832–78,732,889 | 132.1 kb | Distal (>10kb) Multiome | 84 | |
| chr12:78,840,376–78,841,266 | 23.9 kb | Distal (>10kb) Multiome | 115 | |
| chr12:78,863,057–78,865,767 | 1.0 kb | Proximal (<10kb) Multiome | 494 |
Genomic view of the SYT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.