OPA1

OPA1 mitochondrial dynamin like GTPase | FLJ12460, KIAA0567, MGM1, NPG, NTG

The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]

Member of: DE-9 DE-9.3

Biological processes 70 terms

GTP binding (GO:0005525)GTP metabolic process (GO:0046039)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase-dependent fusogenic activity (GO:0140523)GTPase-dependent fusogenic activity (GO:0140523)axon cytoplasm (GO:1904115)axonal transport of mitochondrion (GO:0019896)cardiolipin binding (GO:1901612)cellular senescence (GO:0090398)cristae formation (GO:0042407)cristae formation (GO:0042407)cristae formation (GO:0042407)cytoplasm (GO:0005737)dendrite (GO:0030425)dendrite (GO:0030425)inner mitochondrial membrane organization (GO:0007007)inner mitochondrial membrane organization (GO:0007007)magnesium ion binding (GO:0000287)membrane (GO:0016020)membrane bending activity (GO:0180020)membrane fusion (GO:0061025)membrane tubulation (GO:0097749)microtubule (GO:0005874)microtubule binding (GO:0008017)mitochondrial crista (GO:0030061)mitochondrial fission (GO:0000266)mitochondrial fusion (GO:0008053)mitochondrial fusion (GO:0008053)mitochondrial fusion (GO:0008053)mitochondrial fusion (GO:0008053)mitochondrial fusion (GO:0008053)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane fusion (GO:1990627)mitochondrial inner membrane fusion (GO:1990627)mitochondrial intermembrane space (GO:0005758)mitochondrial intermembrane space (GO:0005758)mitochondrial intermembrane space (GO:0005758)mitochondrial intermembrane space (GO:0005758)mitochondrial intermembrane space (GO:0005758)mitochondrial membrane (GO:0031966)mitochondrial outer membrane (GO:0005741)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)negative regulation of apoptotic process (GO:0043066)negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902236)negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902236)negative regulation of intrinsic apoptotic signaling pathway (GO:2001243)negative regulation of release of cytochrome c from mitochondria (GO:0090201)negative regulation of release of cytochrome c from mitochondria (GO:0090201)peroxisome fission (GO:0016559)phosphatidic acid binding (GO:0070300)positive regulation of T-helper 17 cell lineage commitment (GO:2000330)positive regulation of T-helper 17 cell lineage commitment (GO:2000330)positive regulation of interleukin-17 production (GO:0032740)positive regulation of interleukin-17 production (GO:0032740)protein binding (GO:0005515)protein complex oligomerization (GO:0051259)regulation of mitochondrion organization (GO:0010821)visual perception (GO:0007601)

Expression (TPM)

TFs regulating OPA1 0 TFs

Transcription factors with Perturb-seq knockdown data for OPA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OPA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to OPA1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OPA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:192,788,635–192,789,830	803.8 kb	Distal (>10kb) Multiome HiCAR	148
chr3:193,592,681–193,593,759	6 bp	At TSS Multiome	1031
chr3:193,596,619–193,597,490	4.0 kb	Proximal (<10kb) Multiome	101
chr3:193,598,286–193,598,508	5.1 kb	Proximal (<10kb)	52
chr3:193,745,018–193,745,738	152.3 kb	Distal (>10kb) Multiome	401
chr3:193,775,262–193,776,121	182.7 kb	Distal (>10kb) Multiome	253
chr3:193,788,186–193,788,719	195.2 kb	Distal (>10kb) Multiome	340
chr3:193,812,265–193,813,797	220.1 kb	Distal (>10kb) Multiome	367
chr3:193,816,705–193,817,416	223.8 kb	Distal (>10kb) Multiome	333
chr3:193,851,297–193,851,877	258.4 kb	Distal (>10kb) Multiome	162
chr3:193,879,180–193,880,115	286.7 kb	Distal (>10kb) Multiome	202

Genome Browser

Genomic view of the OPA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.