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DE-9.4

Submodule 16 genes

Mitochondrial oxidative phosphorylation and respiratory chain

This 16-gene module includes MT-ATP6, MT-ND4, MT-ND2, and MT-CO1, and is enriched for respiratory chain complex components, proton transmembrane transporter activity, and oxidative phosphorylation. The genes show strong enrichment for ATP synthesis coupled electron transport and aerobic respiration functions. Knockdown of SOX17 activates this module.

Key terms: oxidative phosphorylation ATP synthesis coupled electron transport aerobic respiration cellular respiration Notable genes: MT-ATP6 PLCG2 MT-ND4 MT-ND2 MT-CO1 MT-ND3 MT-CO2 MT-CYB Top TFs: SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (14)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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