The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for PLCG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLCG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLCG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:81,558,602–81,559,161 | 220.3 kb | Distal (>10kb) Multiome | 376 | |
| chr16:81,634,541–81,635,252 | 144.4 kb | Distal (>10kb) Multiome | 306 | |
| chr16:81,729,445–81,731,113 | 48.8 kb | Distal (>10kb) Multiome | 754 | |
| chr16:81,737,865–81,738,303 | 41.2 kb | Distal (>10kb) Multiome | 489 | |
| chr16:81,778,844–81,779,928 | 66 bp | At TSS Multiome | 538 | |
| chr16:81,784,102–81,784,987 | 5.3 kb | Proximal (<10kb) Multiome | 131 |
Genomic view of the PLCG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.