DE-9 ›

DE-9.1

Submodule 54 genes

Morphogenesis and signaling receptor development

This 54-gene module includes ERBB2, CDH1, POU5F1, DNMT3B, and RYR2, with enrichment in anatomical structure formation involved in morphogenesis, circulatory system development, synapse assembly, and signaling receptor binding and activity. Knockdown of DNAJC19, MARS, ZNF787, ZC3H3, and ZNF532 activates this module. Knockdown of ARID1A, SMARCC1, ZIC3, RREB1, and MIXL1 represses this module.

Key terms: system development multicellular organism development anatomical structure formation involved in morphogenesis anatomical structure development Notable genes: ERBB2 CDH1 POU5F1 DNMT3B RYR2 CD9 PDGFA TERF1 Top TFs: DNAJC19 ARID1A MARS SMARCC1 ZNF787

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (53)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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