The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for PRKD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRKD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRKD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:28,758,498–28,760,371 | 1168.5 kb | Distal (>10kb) Multiome HiCAR | 232 | |
| chr14:28,773,909–28,775,119 | 1153.3 kb | Distal (>10kb) Multiome HiCAR | 225 | |
| chr14:29,925,416–29,925,666 | 2.2 kb | Proximal (<10kb) | 36 | |
| chr14:29,926,094–29,928,788 | 132 bp | At TSS Multiome | 594 | |
| chr14:30,131,614–30,132,503 | 204.1 kb | Distal (>10kb) Multiome | 111 |
Genomic view of the PRKD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.