IGFBP4

insulin like growth factor binding protein 4 | BP-4, HT29-IGFBP, IBP4, IGFBP-4

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

Member of: DE-9 DE-9.7 Developmental clusters: GC3

Biological processes 13 terms

endoplasmic reticulum lumen (GO:0005788)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)insulin-like growth factor I binding (GO:0031994)insulin-like growth factor II binding (GO:0031995)insulin-like growth factor binding (GO:0005520)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)protein binding (GO:0005515)regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)signal transduction (GO:0007165)signaling receptor binding (GO:0005102)

Expression (TPM)

TFs regulating IGFBP4 0 TFs

Transcription factors with Perturb-seq knockdown data for IGFBP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGFBP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to IGFBP4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGFBP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:40,177,152–40,178,398	266.0 kb	Distal (>10kb) Multiome	329
chr17:40,191,326–40,192,022	251.7 kb	Distal (>10kb) Multiome	588
chr17:40,218,712–40,219,963	224.1 kb	Distal (>10kb) Multiome	901
chr17:40,287,308–40,288,608	155.7 kb	Distal (>10kb) Multiome	870
chr17:40,306,565–40,307,697	136.4 kb	Distal (>10kb) Multiome	366
chr17:40,316,576–40,317,119	126.7 kb	Distal (>10kb) Multiome	557
chr17:40,317,794–40,318,727	125.2 kb	Distal (>10kb) Multiome	799
chr17:40,341,205–40,342,644	101.5 kb	Distal (>10kb) Multiome	835
chr17:40,344,939–40,346,042	98.1 kb	Distal (>10kb) Multiome	730
chr17:40,362,469–40,363,831	80.6 kb	Distal (>10kb) Multiome	846
chr17:40,417,289–40,418,494	25.4 kb	Distal (>10kb) Multiome	793
chr17:40,422,953–40,423,555	20.2 kb	Distal (>10kb) Multiome	242
chr17:40,433,731–40,433,926	9.5 kb	Proximal (<10kb)	126
chr17:40,442,866–40,444,146	29 bp	At TSS Multiome	774
chr17:40,483,550–40,484,556	40.5 kb	Distal (>10kb) Multiome	84
chr17:40,499,140–40,499,767	56.1 kb	Distal (>10kb) Multiome	358
chr17:40,615,478–40,615,916	172.3 kb	Distal (>10kb) Multiome	297
chr17:40,637,853–40,638,362	194.7 kb	Distal (>10kb) Multiome	83
chr17:40,735,202–40,736,205	292.2 kb	Distal (>10kb) Multiome	21

Genome Browser

Genomic view of the IGFBP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.