IGFBP2
insulin like growth factor binding protein 2 | IBP2

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Member of: DE-9 DE-9.6 Developmental clusters: GC6
Biological processes 35 terms
apical plasma membrane (GO:0016324)cellular response to hormone stimulus (GO:0032870)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)female pregnancy (GO:0007565)insulin-like growth factor I binding (GO:0031994)insulin-like growth factor I binding (GO:0031994)insulin-like growth factor I binding (GO:0031994)insulin-like growth factor II binding (GO:0031995)insulin-like growth factor II binding (GO:0031995)insulin-like growth factor II binding (GO:0031995)insulin-like growth factor binding (GO:0005520)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)osteoblast differentiation (GO:0001649)positive regulation of activated T cell proliferation (GO:0042104)protein binding (GO:0005515)receptor ligand inhibitor activity (GO:0141069)regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)response to estradiol (GO:0032355)response to estrogen (GO:0043627)response to glucocorticoid (GO:0051384)response to mechanical stimulus (GO:0009612)response to nutrient (GO:0007584)response to retinoic acid (GO:0032526)response to steroid hormone (GO:0048545)response to xenobiotic stimulus (GO:0009410)signaling receptor binding (GO:0005102)
Expression (TPM)
IGFBP2 — as a Regulated Gene

TFs regulating IGFBP2 0 TFs

Transcription factors with Perturb-seq knockdown data for IGFBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGFBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to IGFBP2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGFBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:216,339,679–216,340,452 293.3 kb Distal (>10kb) Multiome 192
chr2:216,345,559–216,346,320 287.4 kb Distal (>10kb) Multiome 100
chr2:216,370,964–216,372,465 261.1 kb Distal (>10kb) Multiome 850
chr2:216,412,020–216,413,196 220.9 kb Distal (>10kb) Multiome 882
chr2:216,498,326–216,499,289 134.6 kb Distal (>10kb) Multiome 982
chr2:216,606,380–216,607,387 26.6 kb Distal (>10kb) Multiome 243
chr2:216,619,507–216,620,419 13.5 kb Distal (>10kb) Multiome 382
chr2:216,632,597–216,634,235 74 bp At TSS Multiome 459
chr2:216,635,691–216,637,041 3.4 kb Proximal (<10kb) Multiome 263
chr2:216,665,266–216,666,969 32.3 kb Distal (>10kb) Multiome 454
chr2:216,691,972–216,693,060 58.8 kb Distal (>10kb) Multiome 383
chr2:216,694,105–216,695,084 61.1 kb Distal (>10kb) Multiome 316
chr2:216,695,439–216,696,027 62.3 kb Distal (>10kb) Multiome 258
chr2:216,765,712–216,766,366 132.6 kb Distal (>10kb) Multiome 240
chr2:216,777,662–216,778,166 144.4 kb Distal (>10kb) Multiome 399
chr2:217,756,309–217,757,077 1123.3 kb Distal (>10kb) Multiome HiCAR 391

Genome Browser

Genomic view of the IGFBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:216,329,679 – 217,767,077
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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