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DE-9.6

Submodule 13 genes

TGF signaling and cell adhesion genes

This module contains 13 genes including FKBP5, IGFBP2, TGFBR3, and EPHA7, enriched for transforming growth factor signaling and ephrin receptor activity. Knockdown of SOX17 activates this module. Knockdown of ARID1A represses this module.

Key terms: cellular developmental process cell differentiation muscular septum morphogenesis T cell proliferation Notable genes: FKBP5 IGFBP2 TGFBR3 CAMK1D EPHA7 GAS7 CNTN4 MDGA2 Top TFs: ARID1A SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (11)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z
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