MT-ND4

NADH dehydrogenase subunit 4 | NAD4, ND4, LHON, MTND4

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Parkinson's disease; macular degeneration; and schizophrenia. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-9 DE-9.4 Developmental clusters: GC3

Biological processes 27 terms

ATP synthesis coupled electron transport (GO:0042773)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase activity (GO:0003954)aerobic respiration (GO:0009060)aerobic respiration (GO:0009060)cerebellum development (GO:0021549)electron transport coupled proton transport (GO:0015990)in utero embryonic development (GO:0001701)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial respiratory chain complex I assembly (GO:0032981)mitochondrion (GO:0005739)proton motive force-driven mitochondrial ATP synthesis (GO:0042776)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)response to ethanol (GO:0045471)response to hypoxia (GO:0001666)response to nicotine (GO:0035094)ubiquinone binding (GO:0048039)

Expression (TPM)