CDH1

cadherin 1 | CD324, uvomorulin, UVO

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Member of: DE-9 DE-9.1 Developmental clusters: GC3

Biological processes 94 terms

GTPase activating protein binding (GO:0032794)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi lumen (GO:0005796)Golgi membrane (GO:0000139)actin cytoskeleton (GO:0015629)adherens junction (GO:0005912)adherens junction (GO:0005912)adherens junction (GO:0005912)adherens junction organization (GO:0034332)adherens junction organization (GO:0034332)ankyrin binding (GO:0030506)apical junction complex (GO:0043296)apical junction complex (GO:0043296)beta-catenin binding (GO:0008013)beta-catenin binding (GO:0008013)beta-catenin binding (GO:0008013)beta-catenin binding (GO:0008013)cadherin binding (GO:0045296)cadherin binding (GO:0045296)calcium ion binding (GO:0005509)calcium-dependent cell-cell adhesion (GO:0016339)catenin complex (GO:0016342)catenin complex (GO:0016342)cell adhesion (GO:0007155)cell adhesion mediator activity (GO:0098631)cell adhesion molecule binding (GO:0050839)cell adhesion molecule binding (GO:0050839)cell junction (GO:0030054)cell junction (GO:0030054)cell junction (GO:0030054)cell junction assembly (GO:0034329)cell migration (GO:0016477)cell morphogenesis (GO:0000902)cell-cell adhesion (GO:0098609)cell-cell adhesion (GO:0098609)cell-cell adhesion mediated by cadherin (GO:0044331)cell-cell adhesion mediated by cadherin (GO:0044331)cell-cell junction assembly (GO:0007043)cellular response to indole-3-methanol (GO:0071681)cellular response to lithium ion (GO:0071285)cortical actin cytoskeleton (GO:0030864)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)desmosome (GO:0030057)desmosome (GO:0030057)desmosome assembly (GO:0002159)early endosome membrane (GO:0031901)endoplasmic reticulum lumen (GO:0005788)endoplasmic reticulum membrane (GO:0005789)endosome (GO:0005768)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)flotillin complex (GO:0016600)flotillin complex (GO:0016600)gamma-catenin binding (GO:0045295)glutamatergic synapse (GO:0098978)homophilic cell-cell adhesion (GO:0007156)homophilic cell-cell adhesion (GO:0007156)identical protein binding (GO:0042802)lamellipodium (GO:0030027)lateral plasma membrane (GO:0016328)lysosomal membrane (GO:0005765)membrane (GO:0016020)membrane (GO:0016020)negative regulation of axon extension (GO:0030517)negative regulation of cell migration (GO:0030336)negative regulation of cell-cell adhesion (GO:0022408)neuron projection development (GO:0031175)perinuclear region of cytoplasm (GO:0048471)pituitary gland development (GO:0021983)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of protein import into nucleus (GO:0042307)positive regulation of protein localization (GO:1903829)postsynapse (GO:0098794)protein binding (GO:0005515)protein localization to plasma membrane (GO:0072659)protein localization to plasma membrane (GO:0072659)protein tyrosine kinase binding (GO:1990782)regulation of gene expression (GO:0010468)regulation of protein catabolic process at postsynapse, modulating synaptic transmission (GO:0099576)response to Gram-positive bacterium (GO:0140459)response to heparin (GO:0071503)response to toxic substance (GO:0009636)response to xenobiotic stimulus (GO:0009410)synapse assembly (GO:0007416)synapse assembly (GO:0007416)trans-Golgi network (GO:0005802)

Expression (TPM)

TFs regulating CDH1 0 TFs

Transcription factors with Perturb-seq knockdown data for CDH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CDH1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:68,447,981–68,449,250	288.7 kb	Distal (>10kb) Multiome	795
chr16:68,520,489–68,521,019	216.5 kb	Distal (>10kb) Multiome	602
chr16:68,528,418–68,529,128	208.6 kb	Distal (>10kb) Multiome	552
chr16:68,529,733–68,530,671	207.1 kb	Distal (>10kb) Multiome	831
chr16:68,538,873–68,540,027	198.0 kb	Distal (>10kb) Multiome	764
chr16:68,642,503–68,643,044	94.6 kb	Distal (>10kb) Multiome	288
chr16:68,644,824–68,646,405	92.0 kb	Distal (>10kb) Multiome	442
chr16:68,732,098–68,732,275	5.0 kb	Proximal (<10kb)	370
chr16:68,736,847–68,738,492	70 bp	At TSS Multiome	537
chr16:68,778,480–68,779,271	41.7 kb	Distal (>10kb) Multiome	248
chr16:68,843,238–68,844,359	106.5 kb	Distal (>10kb) Multiome	918

Genome Browser

Genomic view of the CDH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.