Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GRIK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRIK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRIK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:101,226,456–101,227,530 | 171.9 kb | Distal (>10kb) Multiome | 187 | |
| chr6:101,391,729–101,394,331 | 5.1 kb | Proximal (<10kb) Multiome | 490 | |
| chr6:101,396,671–101,396,845 | 2.0 kb | Proximal (<10kb) | 178 | |
| chr6:101,397,298–101,397,495 | 1.3 kb | Proximal (<10kb) | 54 | |
| chr6:101,398,753–101,400,044 | at TSS | At TSS | 181 | |
| chr6:101,401,610–101,403,916 | 4.0 kb | Proximal (<10kb) Multiome | 418 | |
| chr6:101,459,860–101,461,544 | 61.6 kb | Distal (>10kb) Multiome | 129 | |
| chr6:102,570,565–102,571,727 | 1172.4 kb | Distal (>10kb) Multiome HiCAR | 131 |
Genomic view of the GRIK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.