This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]
Transcription factors with Perturb-seq knockdown data for NRP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:33,041,579–33,042,769 | 292.9 kb | Distal (>10kb) Multiome | 168 | |
| chr10:33,236,801–33,237,454 | 97.9 kb | Distal (>10kb) Multiome | 118 | |
| chr10:33,315,670–33,316,325 | 19.1 kb | Distal (>10kb) Multiome | 148 | |
| chr10:33,327,722–33,328,284 | 6.8 kb | Proximal (<10kb) | 95 | |
| chr10:33,330,415–33,331,802 | 3.8 kb | Proximal (<10kb) Multiome | 473 | |
| chr10:33,334,043–33,337,287 | 69 bp | At TSS Multiome | 757 | |
| chr10:33,337,395–33,337,531 | 2.3 kb | Proximal (<10kb) | 89 | |
| chr10:34,212,969–34,213,998 | 878.5 kb | Distal (>10kb) Multiome HiCAR | 401 | |
| chr10:34,504,225–34,505,638 | 1169.7 kb | Distal (>10kb) Multiome HiCAR | 220 |
Genomic view of the NRP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.