The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for FKBP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FKBP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FKBP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:35,451,927–35,453,018 | 236.6 kb | Distal (>10kb) Multiome | 799 | |
| chr6:35,467,935–35,469,331 | 220.6 kb | Distal (>10kb) Multiome | 1091 | |
| chr6:35,485,138–35,486,890 | 202.5 kb | Distal (>10kb) Multiome | 400 | |
| chr6:35,490,011–35,490,813 | 198.6 kb | Distal (>10kb) Multiome | 310 | |
| chr6:35,495,972–35,498,486 | 191.8 kb | Distal (>10kb) Multiome | 939 | |
| chr6:35,522,668–35,523,295 | 166.0 kb | Distal (>10kb) Multiome | 419 | |
| chr6:35,687,984–35,689,594 | 93 bp | At TSS Multiome | 968 | |
| chr6:35,727,435–35,728,457 | 39.0 kb | Distal (>10kb) Multiome | 812 | |
| chr6:35,731,025–35,732,630 | 42.8 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:35,764,004–35,765,052 | 75.6 kb | Distal (>10kb) Multiome | 254 | |
| chr6:35,776,412–35,776,992 | 87.7 kb | Distal (>10kb) Multiome | 410 | |
| chr6:35,804,967–35,805,624 | 116.3 kb | Distal (>10kb) Multiome | 815 | |
| chr6:35,920,112–35,921,529 | 232.2 kb | Distal (>10kb) Multiome | 965 | |
| chr6:35,931,065–35,931,702 | 242.4 kb | Distal (>10kb) Multiome | 77 |
Genomic view of the FKBP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.