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DE-9.7

Submodule 11 genes

TGF-β signaling and extracellular matrix interactions

This 11-gene module includes TGFB1, ITGB1, TNFRSF10B, ADAMTS9, and IGFBP4, with enriched terms related to TGF-β signaling pathway, integrin binding, and extracellular matrix organization. No transcription factor knockdown data are available for this module. No repressing transcription factors have been identified.

Key terms: positive regulation of fibroblast migration extracellular structure organization extracellular matrix organization regulation of collagen metabolic process Notable genes: TGFB1 ITGB1 TNFRSF10B ADAMTS9 IGFBP4 TNFRSF10D ARHGAP31 DCBLD1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (11)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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