The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for NRG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:31,238,723–31,239,626 | 400.2 kb | Distal (>10kb) Multiome HiCAR | 327 | |
| chr8:31,523,545–31,524,228 | 115.3 kb | Distal (>10kb) Multiome | 149 | |
| chr8:31,638,925–31,641,233 | at TSS | At TSS | 371 | |
| chr8:32,383,867–32,384,620 | 745.1 kb | Distal (>10kb) Multiome HiCAR | 77 | |
| chr8:32,394,061–32,395,020 | 755.0 kb | Distal (>10kb) Multiome HiCAR | 94 | |
| chr8:32,547,134–32,547,355 | 853 bp | At TSS | 69 | |
| chr8:32,547,482–32,549,534 | 908.8 kb | Distal (>10kb) Multiome | 586 | |
| chr8:32,554,741–32,555,187 | 6.5 kb | Proximal (<10kb) | 164 | |
| chr8:32,927,696–32,928,504 | 1288.7 kb | Distal (>10kb) Multiome | 353 | |
| chr8:33,120,207–33,121,079 | 1481.4 kb | Distal (>10kb) Multiome HiCAR | 177 |
Genomic view of the NRG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.