This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for TGFBR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TGFBR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TGFBR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:91,500,333–91,501,821 | 385.0 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr1:91,875,920–91,876,662 | 9.9 kb | Proximal (<10kb) Multiome | 176 | |
| chr1:91,884,890–91,887,193 | 78 bp | At TSS Multiome | 882 | |
| chr1:91,892,107–91,892,385 | 6.0 kb | Proximal (<10kb) | 99 | |
| chr1:92,029,331–92,030,637 | 144.0 kb | Distal (>10kb) Multiome | 471 | |
| chr1:92,079,936–92,081,084 | 194.3 kb | Distal (>10kb) Multiome | 692 |
Genomic view of the TGFBR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.