CADM1

cell adhesion molecule 1 | BL2, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, SYNCAM1, IGSF4, TSLC1

Enables signaling receptor binding activity. Involved in several processes, including cell recognition; positive regulation of cytokine production; and susceptibility to natural killer cell mediated cytotoxicity. Located in plasma membrane. Implicated in breast carcinoma and prostate cancer. Biomarker of cervix uteri carcinoma in situ. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-9 DE-9.5 Developmental clusters: GC6

Biological processes 56 terms

PDZ domain binding (GO:0030165)PDZ domain binding (GO:0030165)Schaffer collateral - CA1 synapse (GO:0098685)T cell mediated cytotoxicity (GO:0001913)activated T cell proliferation (GO:0050798)axon (GO:0030424)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)cell recognition (GO:0008037)cell recognition (GO:0008037)cell recognition (GO:0008037)cell recognition (GO:0008037)cell-cell junction (GO:0005911)cell-cell junction (GO:0005911)dendrite (GO:0030425)detection of stimulus (GO:0051606)detection of stimulus (GO:0051606)detection of stimulus (GO:0051606)detection of stimulus (GO:0051606)glutamatergic synapse (GO:0098978)heterophilic cell-cell adhesion (GO:0007157)heterophilic cell-cell adhesion (GO:0007157)homophilic cell-cell adhesion (GO:0007156)homophilic cell-cell adhesion (GO:0007156)homophilic cell-cell adhesion (GO:0007156)identical protein binding (GO:0042802)lymphocyte migration into lymphoid organs (GO:0097021)maintenance of postsynaptic specialization structure (GO:0098880)neuron projection (GO:0043005)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of cytokine production (GO:0001819)positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)postsynaptic membrane (GO:0045211)presynapse assembly (GO:0099054)presynaptic membrane (GO:0042734)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)retrograde trans-synaptic signaling by trans-synaptic protein complex (GO:0098942)signaling receptor binding (GO:0005102)signaling receptor binding (GO:0005102)signaling receptor binding (GO:0005102)signaling receptor binding (GO:0005102)susceptibility to natural killer cell mediated cytotoxicity (GO:0042271)susceptibility to natural killer cell mediated cytotoxicity (GO:0042271)susceptibility to natural killer cell mediated cytotoxicity (GO:0042271)susceptibility to natural killer cell mediated cytotoxicity (GO:0042271)synapse (GO:0045202)synapse (GO:0045202)synaptic membrane adhesion (GO:0099560)synaptic vesicle (GO:0008021)

Expression (TPM)

TFs regulating CADM1 0 TFs

Transcription factors with Perturb-seq knockdown data for CADM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CADM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CADM1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CADM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:115,476,356–115,476,910	27.8 kb	Distal (>10kb) Multiome	175
chr11:115,480,345–115,481,666	23.5 kb	Distal (>10kb) Multiome	79
chr11:115,502,827–115,505,505	166 bp	At TSS Multiome	796
chr11:115,527,692–115,528,443	23.6 kb	Distal (>10kb) Multiome	145
chr11:115,548,842–115,549,404	44.6 kb	Distal (>10kb) Multiome	303
chr11:115,598,370–115,599,233	94.4 kb	Distal (>10kb) Multiome	158
chr11:115,645,708–115,646,618	141.6 kb	Distal (>10kb) Multiome	202
chr11:115,655,636–115,656,914	151.9 kb	Distal (>10kb) Multiome	181
chr11:115,759,478–115,760,505	255.5 kb	Distal (>10kb) Multiome	154
chr11:116,077,925–116,079,072	574.0 kb	Distal (>10kb) Multiome HiCAR	252

Genome Browser

Genomic view of the CADM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.