DE-9 ›

DE-9.3

Submodule 24 genes

Ossification and lipid binding processes

This module contains 24 genes including PTCH1, OPA1, PRKD1, PPP2R2B, and SLC20A2, with enrichment for ossification and lipid binding functions. No transcription factor knockdown data are available for this module, limiting inference of regulatory mechanisms during ESC-to-DE differentiation.

Key terms: ossification osteoblast differentiation Notable genes: PTCH1 OPA1 PRKD1 PPP2R2B SLC20A2 PREX1 LGR4 SH3PXD2A

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (24)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z
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