Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ITGB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:32,948,457–32,949,002 | 9.3 kb | Proximal (<10kb) | 314 | |
| chr10:32,950,586–32,951,108 | 7.2 kb | Proximal (<10kb) | 209 | |
| chr10:32,954,253–32,954,452 | 3.8 kb | Proximal (<10kb) | 81 | |
| chr10:32,956,436–32,956,727 | 1.5 kb | Proximal (<10kb) | 51 | |
| chr10:32,957,333–32,958,991 | 63 bp | At TSS Multiome | 981 | |
| chr10:32,960,217–32,960,369 | 1.9 kb | Proximal (<10kb) | 138 | |
| chr10:32,961,770–32,962,285 | 3.5 kb | Proximal (<10kb) | 240 | |
| chr10:32,980,401–32,981,503 | 22.5 kb | Distal (>10kb) Multiome | 925 | |
| chr10:33,005,307–33,006,128 | 47.5 kb | Distal (>10kb) Multiome | 624 | |
| chr10:33,041,579–33,042,769 | 83.9 kb | Distal (>10kb) Multiome | 168 | |
| chr10:33,236,801–33,237,454 | 278.9 kb | Distal (>10kb) Multiome | 118 |
Genomic view of the ITGB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.