The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for TNFRSF10B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFRSF10B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFRSF10B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,864,299–22,865,847 | 204.0 kb | Distal (>10kb) Multiome | 507 | |
| chr8:22,916,000–22,916,628 | 152.8 kb | Distal (>10kb) Multiome | 199 | |
| chr8:22,998,974–23,000,300 | 69.5 kb | Distal (>10kb) Multiome | 597 | |
| chr8:23,019,069–23,020,109 | 49.6 kb | Distal (>10kb) Multiome | 452 | |
| chr8:23,049,698–23,050,409 | 19.1 kb | Distal (>10kb) Multiome | 277 | |
| chr8:23,067,895–23,068,290 | 740 bp | At TSS | 417 | |
| chr8:23,068,457–23,069,444 | 44 bp | At TSS Multiome | 856 | |
| chr8:23,070,730–23,071,209 | 1.7 kb | Proximal (<10kb) | 29 | |
| chr8:23,083,702–23,084,469 | 15.3 kb | Distal (>10kb) Multiome | 538 | |
| chr8:23,162,920–23,164,386 | 94.9 kb | Distal (>10kb) Multiome | 808 | |
| chr8:23,224,394–23,225,450 | 156.0 kb | Distal (>10kb) Multiome | 678 | |
| chr8:23,246,206–23,247,324 | 177.6 kb | Distal (>10kb) Multiome | 941 | |
| chr8:23,287,908–23,288,715 | 219.1 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the TNFRSF10B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.