The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for ITPR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:26,195,307–26,196,297 | 298.4 kb | Distal (>10kb) Multiome | 353 | |
| chr12:26,679,082–26,679,573 | 185.0 kb | Distal (>10kb) Multiome | 121 | |
| chr12:26,831,973–26,834,292 | 339.1 kb | Distal (>10kb) Multiome | 945 | |
| chr12:26,884,786–26,885,430 | 390.8 kb | Distal (>10kb) Multiome | 412 | |
| chr12:26,937,248–26,939,182 | 444.0 kb | Distal (>10kb) Multiome | 853 | |
| chr12:27,013,686–27,014,988 | 520.2 kb | Distal (>10kb) Multiome | 864 | |
| chr12:27,021,899–27,022,924 | 528.3 kb | Distal (>10kb) Multiome | 783 |
Genomic view of the ITPR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.