chr12:113,477,415–113,477,998

chr12 : 113,477,415 – 113,477,998

583 bp 71 TFs 8 linked genes

This 583 bp open chromatin element is linked to 8 target genes and is bound by 71 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
LHX5-AS1		5.4 kb	Proximal	Proximity
LHX5		5.5 kb	Proximal	Proximity
PLBD2		119.0 kb	Distal	Multiome
SLC8B1		142.5 kb	Distal	Multiome
TPCN1		256.2 kb	Distal	Multiome
RITA1		292.1 kb	Distal	Multiome
DDX54		292.2 kb	Distal	Multiome
LINC01234		296.1 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

71 transcription factors

ASH2L 1 dataset

ChIP H1 ENCFF399KAM 356 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 208 bp overlap

BCOR 2 datasets

ChIP WA01 GSE104690.BCOR.WA01 583 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 449 bp overlap

BRD1 2 datasets

ChIP HUES-64 GSE104059.BRD1.HUES-64 410 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 80 bp overlap

BRD4 3 datasets

ChIP K-562_iBET-IFNG GSE138084.BRD4.K-562_iBET-IFNG 208 bp overlap

ChIP hESC GSE33281.BRD4.hESC 68 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 398 bp overlap

CBFA2T2 1 dataset

ChIP NCCIT GSE71675.CBFA2T2.NCCIT 255 bp overlap

CHD1 2 datasets

ChIP H1 ENCFF998XEK 289 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 583 bp overlap

CHD7 2 datasets

ChIP H1 ENCFF126NLU 436 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 278 bp overlap

CREB1 1 dataset

ChIP WA01 ENCSR000BSN.CREB1.WA01 103 bp overlap

CTBP2 3 datasets

ChIP H1 ENCFF329MAX 290 bp overlap

ChIP H1 ENCFF329MAX 571 bp overlap

ChIP WA01 ENCSR000EUO.CTBP2.WA01 557 bp overlap

CTCF 8 datasets

ChIP GM12866 ENCSR000DRF.CTCF.GM12866 113 bp overlap

ChIP H1 ENCFF764RHO 277 bp overlap

ChIP H9 ENCFF152GTF 433 bp overlap

ChIP hESC_D0 GSE116862.CTCF.hESC_D0 156 bp overlap

ChIP hiPSC_Angelman GSE117283.CTCF.hiPSC_Angelman 176 bp overlap

ChIP hiPSC_Prader-Willi GSE117283.CTCF.hiPSC_Prader-Willi 186 bp overlap

ChIP neural progenitor cell ENCFF420RBO 411 bp overlap

ChIP neural_progenitor ENCSR125NBL.CTCF.neural_progenitor 243 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 136 bp overlap

EGR1 3 datasets

ChIP A-375 GSE116190.EGR1.A-375 215 bp overlap

ChIP H1 ENCFF451BLH 261 bp overlap

ChIP WA01 ENCSR000BJA.EGR1.WA01 279 bp overlap

ChIP WA01 ERP002417.ELK1.WA01 204 bp overlap

ERF::FOXO1 1 dataset

Motif ES_0h ES_0h-ERFFOXO1_MA1936.2 12 bp overlap

ETS1 3 datasets

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 583 bp overlap

ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 228 bp overlap

ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 161 bp overlap

ChIP WTC11 ENCFF812SCD 282 bp overlap

EZH2 27 datasets

ChIP GM23338 ENCFF613YON 89 bp overlap

ChIP GM23338 ENCFF613YON 221 bp overlap

ChIP H1 ENCFF232NZA 583 bp overlap

ChIP HUVEC-C GSE109625.EZH2.HUVEC-C 319 bp overlap

ChIP HUVEC-C GSE109625.EZH2.HUVEC-C 101 bp overlap

ChIP Hep-G2 ENCSR000ARI.EZH2.Hep-G2 296 bp overlap

ChIP LNCaP GSE39459.EZH2.LNCaP 109 bp overlap

ChIP LNCaP GSE39459.EZH2.LNCaP 326 bp overlap

ChIP PC-9 ENCSR793USK.EZH2.PC-9 410 bp overlap

ChIP SK-N-MC ENCFF674XUJ 448 bp overlap

ChIP SU-DHL-6 GSE134136.EZH2.SU-DHL-6 257 bp overlap

ChIP T98G GSE112240.EZH2.T98G 517 bp overlap

ChIP VCaP_DHAT_2H GSE28950.EZH2.VCaP_DHAT_2H 583 bp overlap

ChIP VCaP_ETOH GSE28950.EZH2.VCaP_ETOH 403 bp overlap

ChIP VCaP_ETOH GSE28950.EZH2.VCaP_ETOH 88 bp overlap

ChIP dermal-fibroblast_Preneoplastic GSE126396.EZH2.dermal-fibroblast_Preneoplastic 304 bp overlap

ChIP dermal-fibroblast_Transformed GSE126396.EZH2.dermal-fibroblast_Transformed 435 bp overlap

ChIP dermal-fibroblast_Untransformed GSE126396.EZH2.dermal-fibroblast_Untransformed 583 bp overlap

ChIP endothelial_umbilical-vein ENCSR000ATA.EZH2.endothelial_umbilical-vein 528 bp overlap

ChIP fibroblast of lung ENCFF479BAW 184 bp overlap

ChIP hepatocyte ENCFF118DKH 119 bp overlap

ChIP hepatocyte ENCFF118DKH 320 bp overlap

ChIP keratinocyte ENCFF070STK 488 bp overlap

ChIP keratinocyte ENCFF070STK 340 bp overlap

ChIP mammary epithelial cell ENCFF224GAI 123 bp overlap

ChIP skeletal muscle myoblast ENCFF338LNF 421 bp overlap

ChIP skeletal muscle myoblast ENCFF338LNF 133 bp overlap

EZH2_phosphoT487 2 datasets

ChIP GM23248 ENCSR096KPA.EZH2_phosphoT487.GM23248 207 bp overlap

ChIP PC-3 ENCSR617RSQ.EZH2_phosphoT487.PC-3 494 bp overlap

FOXO1::ELF1 1 dataset

Motif ES_0h ES_0h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXP1 2 datasets

ChIP H9 GSE31006.FOXP1.H9 143 bp overlap

ChIP WTC11 ENCFF338WGC 360 bp overlap

FOXP4 1 dataset

ChIP WTC11 ENCFF708TAF 332 bp overlap

GABPA 1 dataset

ChIP H1 ENCFF739QFD 325 bp overlap

GATA6 3 datasets

ChIP DE_D1 S41-DE-d1-GATA6-exp2 420 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 510 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 432 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 456 bp overlap

GRHL2 1 dataset

Motif ES_0h ES_0h-GRHL2_MA1105.3 8 bp overlap

Motif ES_0h ES_0h-Gli2_MA0734.4 9 bp overlap

HCFC1R1 1 dataset

ChIP cartilage GSE100311.HCFC1R1.cartilage 310 bp overlap

HDAC2 2 datasets

ChIP H1 ENCFF353UJQ 568 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 542 bp overlap

Hand1::Tcf3 1 dataset

Motif ES_0h ES_0h-Hand1Tcf3_MA0092.2 9 bp overlap

JARID2 4 datasets

ChIP AMIPS6 GSE48516.JARID2.AMIPS6 284 bp overlap

ChIP EDOMIPS2 GSE48516.JARID2.EDOMIPS2 403 bp overlap

ChIP UTEIPS4 GSE48516.JARID2.UTEIPS4 488 bp overlap

ChIP UTEIPS6 GSE48516.JARID2.UTEIPS6 550 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 441 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 444 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 348 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 384 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 418 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 431 bp overlap

KDM4A 1 dataset

ChIP H1 ENCFF078LED 230 bp overlap

ChIP H1 ENCFF914VQY 271 bp overlap

ChIP RH30_DMSO GSE85169.MYOG.RH30_DMSO 205 bp overlap

NANOG 1 dataset

ChIP HUES-8 GSE109524.NANOG.HUES-8 583 bp overlap

NFKB1 2 datasets

ChIP HEK293T GSE129618.NFKB1.HEK293T 69 bp overlap

ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 251 bp overlap

NIPBL 1 dataset

ChIP WA09 GSE105028.NIPBL.WA09 130 bp overlap

POU5F1 4 datasets

ChIP BG03 GSE21614.POU5F1.BG03 219 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 583 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 583 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 187 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 196 bp overlap

PRDM1 1 dataset

Motif ES_0h ES_0h-PRDM1_MA0508.4 7 bp overlap

PRDM10 2 datasets

ChIP HEK293 ENCFF145WQQ 115 bp overlap

ChIP K-562 ENCSR120MPG.PRDM10.K-562 133 bp overlap

RAD21 3 datasets

ChIP H1 ENCFF698EWO 241 bp overlap

ChIP WA09 GSE105028.RAD21.WA09 501 bp overlap

ChIP WA09_heat-shock GSE105028.RAD21.WA09_heat-shock 479 bp overlap

RBBP5 3 datasets

ChIP H1 ENCFF905HFL 449 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 280 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 160 bp overlap

REST 7 datasets

ChIP K-562 ENCSR000BMW.REST.K-562 91 bp overlap

ChIP PANC-1 ENCSR000BJO.REST.PANC-1 199 bp overlap

ChIP PANC-1 ENCSR000BPK.REST.PANC-1 233 bp overlap

ChIP PFSK1 ENCSR000BJP.REST.PFSK1 117 bp overlap

ChIP PFSK1 ENCSR000BJP.REST.PFSK1 79 bp overlap

ChIP WA01 ENCSR000BHM.REST.WA01 121 bp overlap

ChIP colorectal-cancer_shCTRL_intact GSE112555.REST.colorectal-cancer_shCTRL_intact 583 bp overlap

RNF2 2 datasets

ChIP HUES-64 GSE104059.RNF2.HUES-64 583 bp overlap

ChIP SYO-1_shCt GSE139053.RNF2.SYO-1_shCt 449 bp overlap

SIN3A 1 dataset

ChIP WA01 ENCSR000EBO.SIN3A.WA01 150 bp overlap

SMAD1 1 dataset

ChIP BG03 GSE36578.SMAD1.BG03 96 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 359 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 465 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 504 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 412 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 387 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 303 bp overlap

SMAD3 1 dataset

ChIP BG03 GSE21614.SMAD3.BG03 228 bp overlap

SMARCA4 3 datasets

ChIP HS-SY-2_HA-tagged GSE108926.SMARCA4.HS-SY-2_HA-tagged 583 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 159 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 138 bp overlap

SOX11 1 dataset

ChIP GRANT-A519 GSE52146.SOX11.GRANT-A519 90 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 183 bp overlap

ChIP WA01 ENCSR000BQV.SP4.WA01 165 bp overlap

SPI1 2 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 125 bp overlap

ChIP DC_LPS GSE123347.SPI1.DC_LPS 107 bp overlap

ChIP OCI-Ly3 GSE56857.SPIB.OCI-Ly3 215 bp overlap

SS18-SSX 1 dataset

ChIP fibroblast_78aa-SSX-Tail GSE139053.SS18-SSX.fibroblast_78aa-SSX-Tail 390 bp overlap

SUZ12 5 datasets

ChIP H1 ENCFF881NFR 583 bp overlap

ChIP HEK293T_PCGF2fl GSE119618.SUZ12.HEK293T_PCGF2fl 210 bp overlap

ChIP K-562 ENCSR000AUC.SUZ12.K-562 204 bp overlap

ChIP LNCaP-abl GSE39459.SUZ12.LNCaP-abl 67 bp overlap

ChIP WA01 ENCSR000ATS.SUZ12.WA01 540 bp overlap

Motif ES_0h ES_0h-TBX5_MA0807.1 8 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 137 bp overlap

TEAD4 2 datasets

ChIP ESC S26-ESC-d0-TEAD4-exp1 506 bp overlap

ChIP H1 ENCFF778PAX 88 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 384 bp overlap

ChIP H1 ENCFF524BTL 274 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 339 bp overlap

ZBTB43 1 dataset

ChIP WTC11 ENCFF058JUB 350 bp overlap

ZNF143 1 dataset

ChIP WA01 ENCSR000EBW.ZNF143.WA01 232 bp overlap

ZNF184 1 dataset

Motif ES_0h ES_0h-ZNF184_MA2120.1 13 bp overlap

ZNF512 1 dataset

ChIP WTC11 ENCFF086TTM 285 bp overlap

Zic1::Zic2 1 dataset

Motif ES_0h ES_0h-Zic1Zic2_MA1628.2 7 bp overlap

Motif ES_0h ES_0h-Zic2_MA1629.2 9 bp overlap

Motif ES_0h ES_0h-Zic3_MA0697.3 7 bp overlap