Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for TPCN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPCN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPCN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:113,092,863–113,093,647 | 128.2 kb | Distal (>10kb) Multiome | 192 | |
| chr12:113,103,783–113,104,453 | 117.4 kb | Distal (>10kb) Multiome | 273 | |
| chr12:113,135,292–113,136,333 | 85.6 kb | Distal (>10kb) Multiome | 375 | |
| chr12:113,149,367–113,149,817 | 71.8 kb | Distal (>10kb) Multiome | 206 | |
| chr12:113,152,822–113,153,581 | 68.2 kb | Distal (>10kb) Multiome | 573 | |
| chr12:113,154,377–113,154,958 | 66.7 kb | Distal (>10kb) Multiome | 182 | |
| chr12:113,161,407–113,162,141 | 59.7 kb | Distal (>10kb) Multiome | 235 | |
| chr12:113,184,669–113,186,034 | 35.9 kb | Distal (>10kb) Multiome | 1020 | |
| chr12:113,220,621–113,222,139 | 121 bp | At TSS Multiome | 818 | |
| chr12:113,245,518–113,246,307 | 24.5 kb | Distal (>10kb) Multiome | 649 | |
| chr12:113,334,690–113,335,505 | 113.7 kb | Distal (>10kb) Multiome | 685 | |
| chr12:113,358,144–113,359,258 | 137.1 kb | Distal (>10kb) Multiome | 774 | |
| chr12:113,379,206–113,379,726 | 158.1 kb | Distal (>10kb) Multiome | 129 | |
| chr12:113,441,054–113,441,740 | 219.9 kb | Distal (>10kb) Multiome | 115 | |
| chr12:113,471,448–113,471,998 | 250.6 kb | Distal (>10kb) Multiome | 98 | |
| chr12:113,477,415–113,477,998 | 256.2 kb | Distal (>10kb) Multiome | 71 | |
| chr12:113,514,969–113,515,472 | 293.9 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the TPCN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.