chr1:168,187,044–168,187,988

chr1 : 168,187,044 – 168,187,988

944 bp 107 TFs 7 linked genes

This 944 bp open chromatin element is linked to 7 target genes and is bound by 107 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TIPRL		8.1 kb	Proximal	Proximity
SFT2D2		38.5 kb	Distal	Multiome
GPR161		49.8 kb	Distal	Multiome
TBX19		103.7 kb	Distal	Multiome
DCAF6		250.8 kb	Distal	Multiome
MPC2		251.4 kb	Distal	Multiome
ADCY10		273.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

107 transcription factors

ASCL1 1 dataset

ChIP SCLC_ASCLP_NE GSE61197.ASCL1.SCLC_ASCLP_NE 118 bp overlap

BHLHE22 3 datasets

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_72h DE_72h-BHLHE22_MA1635.2 6 bp overlap

ChIP CD4_JG1 GSE33281.BRD4.CD4_JG1 278 bp overlap

Bcl11B 3 datasets

Motif DE_48h DE_48h-Bcl11B_MA1989.2 9 bp overlap

Motif DE_60h DE_60h-Bcl11B_MA1989.2 9 bp overlap

Motif DE_72h DE_72h-Bcl11B_MA1989.2 9 bp overlap

Bhlha15 3 datasets

Motif DE_48h DE_48h-Bhlha15_MA1472.3 8 bp overlap

Motif DE_60h DE_60h-Bhlha15_MA1472.3 8 bp overlap

Motif DE_72h DE_72h-Bhlha15_MA1472.3 8 bp overlap

ChIP GSC23 GSE139416.CTCF.GSC23 286 bp overlap

DMRTC2 2 datasets

Motif DE_48h DE_48h-DMRTC2_MA1479.2 11 bp overlap

Motif DE_60h DE_60h-DMRTC2_MA1479.2 11 bp overlap

Dmrt1 1 dataset

Motif DE_48h DE_48h-Dmrt1_MA1603.2 9 bp overlap

EOMES 3 datasets

Motif DE_48h DE_48h-EOMES_MA0800.2 9 bp overlap

Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 299 bp overlap

ETV5::FOXO1 1 dataset

Motif DE_48h DE_48h-ETV5FOXO1_MA1947.2 10 bp overlap

FOXA2 4 datasets

ChIP DE DE-FOXA2-1 800 bp overlap

ChIP DE DE-FOXA2-2 752 bp overlap

ChIP KerCT GSE90454.FOXA2.KerCT 358 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 332 bp overlap

FOXB1 2 datasets

Motif DE_48h DE_48h-FOXB1_MA0845.1 11 bp overlap

Motif DE_60h DE_60h-FOXB1_MA0845.1 11 bp overlap

FOXC2 3 datasets

Motif DE_48h DE_48h-FOXC2_MA0846.2 11 bp overlap

Motif DE_60h DE_60h-FOXC2_MA0846.2 11 bp overlap

Motif DE_72h DE_72h-FOXC2_MA0846.2 11 bp overlap

FOXD2 3 datasets

Motif DE_48h DE_48h-FOXD2_MA0847.4 11 bp overlap

Motif DE_60h DE_60h-FOXD2_MA0847.4 11 bp overlap

Motif DE_72h DE_72h-FOXD2_MA0847.4 11 bp overlap

FOXE1 3 datasets

Motif DE_48h DE_48h-FOXE1_MA1487.3 12 bp overlap

Motif DE_60h DE_60h-FOXE1_MA1487.3 12 bp overlap

Motif DE_72h DE_72h-FOXE1_MA1487.3 12 bp overlap

GATA1 1 dataset

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 99 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 551 bp overlap

ChIP DE DE-GATA4-2 673 bp overlap

GATA6 3 datasets

ChIP DE DE-GATA6-1 660 bp overlap

ChIP DE DE-GATA6-2 656 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 375 bp overlap

GFI1 2 datasets

Motif DE_48h DE_48h-GFI1_MA0038.3 11 bp overlap

Motif DE_60h DE_60h-GFI1_MA0038.3 11 bp overlap

GRHL1 1 dataset

Motif DE_48h DE_48h-GRHL1_MA0647.2 10 bp overlap

GRHL2 1 dataset

Motif DE_48h DE_48h-GRHL2_MA1105.3 8 bp overlap

Gfi1B 3 datasets

Motif DE_48h DE_48h-Gfi1B_MA0483.2 10 bp overlap

Motif DE_60h DE_60h-Gfi1B_MA0483.2 10 bp overlap

Motif DE_72h DE_72h-Gfi1B_MA0483.2 10 bp overlap

ChIP K-562 ENCSR197ALX.HDGF.K-562 489 bp overlap

HOXA4 1 dataset

Motif DE_48h DE_48h-HOXA4_MA1496.2 7 bp overlap

HOXB4 3 datasets

Motif DE_48h DE_48h-HOXB4_MA1499.2 6 bp overlap

Motif DE_48h DE_48h-HOXB4_MA1499.2 6 bp overlap

Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap

HOXC4 3 datasets

Motif DE_48h DE_48h-HOXC4_MA1504.2 6 bp overlap

Motif DE_48h DE_48h-HOXC4_MA1504.2 6 bp overlap

Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap

HOXC6 1 dataset

ChIP 22Rv1 GSE129951.HOXC6.22Rv1 408 bp overlap

HOXD4 3 datasets

Motif DE_48h DE_48h-HOXD4_MA1507.2 6 bp overlap

Motif DE_48h DE_48h-HOXD4_MA1507.2 6 bp overlap

Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap

Hoxd13 1 dataset

Motif DE_48h DE_48h-Hoxd13_MA0909.4 7 bp overlap

Motif DE_48h DE_48h-IRF3_MA1418.2 17 bp overlap

JUN::JUNB 1 dataset

Motif DE_48h DE_48h-JUNJUNB_MA1132.2 8 bp overlap

JUND 2 datasets

Motif DE_48h DE_48h-JUND_MA0492.2 11 bp overlap

Motif DE_60h DE_60h-JUND_MA0492.2 11 bp overlap

KDM1A 1 dataset

ChIP pancreatic-progenitor_PP2-KDM1A-inh GSE104840.KDM1A.pancreatic-progenitor_PP2-KDM1A-inh 464 bp overlap

ChIP BJ_INDUCED GSE36570.KLF4.BJ_INDUCED 194 bp overlap

Lhx1 2 datasets

Motif DE_48h DE_48h-Lhx1_MA1518.3 10 bp overlap

Motif DE_60h DE_60h-Lhx1_MA1518.3 10 bp overlap

MAF::NFE2 1 dataset

Motif DE_48h DE_48h-MAFNFE2_MA0501.2 11 bp overlap

Motif DE_48h DE_48h-MAFF_MA0495.4 11 bp overlap

MAFG::NFE2L1 1 dataset

Motif DE_48h DE_48h-MAFGNFE2L1_MA0089.3 11 bp overlap

MEIS1 2 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MGA_MA0801.1 8 bp overlap

Motif DE_60h DE_60h-MGA_MA0801.1 8 bp overlap

MGA::EVX1 1 dataset

Motif DE_48h DE_48h-MGAEVX1_MA1960.2 11 bp overlap

MSANTD3 2 datasets

Motif DE_48h DE_48h-MSANTD3_MA1523.2 7 bp overlap

Motif DE_60h DE_60h-MSANTD3_MA1523.2 7 bp overlap

Motif DE_48h DE_48h-MSC_MA0665.1 10 bp overlap

Motif DE_60h DE_60h-MSC_MA0665.1 10 bp overlap

Motif DE_72h DE_72h-MSC_MA0665.1 10 bp overlap

MYF5 3 datasets

Motif DE_48h DE_48h-MYF5_MA1641.2 8 bp overlap

Motif DE_60h DE_60h-MYF5_MA1641.2 8 bp overlap

Motif DE_72h DE_72h-MYF5_MA1641.2 8 bp overlap

MYOD1 1 dataset

ChIP myoblast GSE50413.MYOD1.myoblast 136 bp overlap

MYOG 3 datasets

Motif DE_48h DE_48h-MYOG_MA0500.3 8 bp overlap

Motif DE_60h DE_60h-MYOG_MA0500.3 8 bp overlap

Motif DE_72h DE_72h-MYOG_MA0500.3 8 bp overlap

Msgn1 2 datasets

Motif DE_48h DE_48h-Msgn1_MA1524.3 10 bp overlap

Motif DE_60h DE_60h-Msgn1_MA1524.3 10 bp overlap

NFIA 2 datasets

Motif DE_48h DE_48h-NFIA_MA0670.2 6 bp overlap

Motif DE_60h DE_60h-NFIA_MA0670.2 6 bp overlap

NFIX 2 datasets

Motif DE_48h DE_48h-NFIX_MA0671.2 6 bp overlap

Motif DE_60h DE_60h-NFIX_MA0671.2 6 bp overlap

NHLH1 3 datasets

Motif DE_48h DE_48h-NHLH1_MA0048.3 9 bp overlap

Motif DE_60h DE_60h-NHLH1_MA0048.3 9 bp overlap

Motif DE_72h DE_72h-NHLH1_MA0048.3 9 bp overlap

NKX2-2 2 datasets

Motif DE_48h DE_48h-NKX2-2_MA1645.2 8 bp overlap

Motif DE_60h DE_60h-NKX2-2_MA1645.2 8 bp overlap

NKX3-1 1 dataset

ChIP islet ERP004003.NKX3-1.islet 285 bp overlap

NR4A1 2 datasets

Motif DE_48h DE_48h-NR4A1_MA1112.3 8 bp overlap

Motif DE_60h DE_60h-NR4A1_MA1112.3 8 bp overlap

NR4A2 2 datasets

Motif DE_48h DE_48h-NR4A2_MA0160.3 8 bp overlap

Motif DE_60h DE_60h-NR4A2_MA0160.3 8 bp overlap

Motif DE_48h DE_48h-NRL_MA0842.3 12 bp overlap

Neurod2 3 datasets

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Motif DE_72h DE_72h-Neurod2_MA1993.2 6 bp overlap

Nfe2l2 1 dataset

Motif DE_48h DE_48h-Nfe2l2_MA0150.3 11 bp overlap

Olig2 3 datasets

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

Motif DE_72h DE_72h-Olig2_MA1997.2 6 bp overlap

ChIP islet ERP001456.PDX1.islet 195 bp overlap

ChIP T-47D-A_R5020 GSE80358.PGR.T-47D-A_R5020 218 bp overlap

PHOX2A 4 datasets

Motif DE_48h DE_48h-PHOX2A_MA0713.1 11 bp overlap

Motif DE_48h DE_48h-PHOX2A_MA0713.1 11 bp overlap

Motif DE_60h DE_60h-PHOX2A_MA0713.1 11 bp overlap

Motif DE_60h DE_60h-PHOX2A_MA0713.1 11 bp overlap

PHOX2B 4 datasets

Motif DE_48h DE_48h-PHOX2B_MA0681.3 12 bp overlap

Motif DE_48h DE_48h-PHOX2B_MA0681.3 12 bp overlap

Motif DE_60h DE_60h-PHOX2B_MA0681.3 12 bp overlap

Motif DE_60h DE_60h-PHOX2B_MA0681.3 12 bp overlap

PKNOX2 2 datasets

Motif DE_48h DE_48h-PKNOX2_MA0783.1 12 bp overlap

Motif DE_60h DE_60h-PKNOX2_MA0783.1 12 bp overlap

POU6F1 3 datasets

Motif DE_48h DE_48h-POU6F1_MA1549.2 7 bp overlap

Motif DE_48h DE_48h-POU6F1_MA1549.2 7 bp overlap

Motif DE_60h DE_60h-POU6F1_MA1549.2 7 bp overlap

POU6F2 2 datasets

Motif DE_48h DE_48h-POU6F2_MA0793.2 9 bp overlap

Motif DE_60h DE_60h-POU6F2_MA0793.2 9 bp overlap

PRDM6 1 dataset

ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 538 bp overlap

PROP1 4 datasets

Motif DE_48h DE_48h-PROP1_MA0715.1 11 bp overlap

Motif DE_48h DE_48h-PROP1_MA0715.1 11 bp overlap

Motif DE_60h DE_60h-PROP1_MA0715.1 11 bp overlap

Motif DE_60h DE_60h-PROP1_MA0715.1 11 bp overlap

Ptf1A 6 datasets

Motif DE_48h DE_48h-Ptf1A_MA1619.2 8 bp overlap

Motif DE_48h DE_48h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_60h DE_60h-Ptf1A_MA1619.2 8 bp overlap

Motif DE_60h DE_60h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_72h DE_72h-Ptf1A_MA1619.2 8 bp overlap

Motif DE_72h DE_72h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

Motif DE_48h DE_48h-RORA_MA0072.2 11 bp overlap

RUNX1T1 1 dataset

ChIP Kasumi-1_E2 GSE102697.RUNX1T1.Kasumi-1_E2 153 bp overlap

Runx1 3 datasets

Motif DE_48h DE_48h-Runx1_MA0002.3 9 bp overlap

Motif DE_60h DE_60h-Runx1_MA0002.3 9 bp overlap

Motif DE_72h DE_72h-Runx1_MA0002.3 9 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 306 bp overlap

SMAD2_3 1 dataset

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 252 bp overlap

SOX10 1 dataset

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

SOX12 2 datasets

Motif DE_48h DE_48h-SOX12_MA1561.2 10 bp overlap

Motif DE_60h DE_60h-SOX12_MA1561.2 10 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 331 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 624 bp overlap

STAT1::STAT2 1 dataset

Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap

TBR1 2 datasets

Motif DE_48h DE_48h-TBR1_MA0802.2 9 bp overlap

Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap

TBX1 2 datasets

Motif DE_48h DE_48h-TBX1_MA0805.1 8 bp overlap

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

TBX15 2 datasets

Motif DE_48h DE_48h-TBX15_MA0803.1 8 bp overlap

Motif DE_60h DE_60h-TBX15_MA0803.1 8 bp overlap

TBX18 2 datasets

Motif DE_48h DE_48h-TBX18_MA1565.2 9 bp overlap

Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap

TBX2 2 datasets

Motif DE_48h DE_48h-TBX2_MA0688.2 9 bp overlap

Motif DE_60h DE_60h-TBX2_MA0688.2 9 bp overlap

TBX20 2 datasets

Motif DE_48h DE_48h-TBX20_MA0689.1 11 bp overlap

Motif DE_60h DE_60h-TBX20_MA0689.1 11 bp overlap

TBX21 2 datasets

Motif DE_48h DE_48h-TBX21_MA0690.3 10 bp overlap

Motif DE_60h DE_60h-TBX21_MA0690.3 10 bp overlap

TBX3 2 datasets

Motif DE_48h DE_48h-TBX3_MA1566.3 9 bp overlap

Motif DE_60h DE_60h-TBX3_MA1566.3 9 bp overlap

TBX4 2 datasets

Motif DE_48h DE_48h-TBX4_MA0806.1 8 bp overlap

Motif DE_60h DE_60h-TBX4_MA0806.1 8 bp overlap

TBX5 2 datasets

Motif DE_48h DE_48h-TBX5_MA0807.1 8 bp overlap

Motif DE_60h DE_60h-TBX5_MA0807.1 8 bp overlap

TFAP4 3 datasets

Motif DE_48h DE_48h-TFAP4_MA0691.1 10 bp overlap

Motif DE_60h DE_60h-TFAP4_MA0691.1 10 bp overlap

Motif DE_72h DE_72h-TFAP4_MA0691.1 10 bp overlap

TGIF1 2 datasets

Motif DE_48h DE_48h-TGIF1_MA0796.1 12 bp overlap

Motif DE_60h DE_60h-TGIF1_MA0796.1 12 bp overlap

TGIF2 2 datasets

Motif DE_48h DE_48h-TGIF2_MA0797.1 12 bp overlap

Motif DE_60h DE_60h-TGIF2_MA0797.1 12 bp overlap

Tbx6 2 datasets

Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap

Motif DE_60h DE_60h-Tbx6_MA1567.3 9 bp overlap

Tcf12 3 datasets

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Motif DE_72h DE_72h-Tcf12_MA0521.3 6 bp overlap

Twist2 3 datasets

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

Motif DE_72h DE_72h-Twist2_MA0633.3 6 bp overlap

ZBTB18 3 datasets

Motif DE_48h DE_48h-ZBTB18_MA0698.2 11 bp overlap

Motif DE_60h DE_60h-ZBTB18_MA0698.2 11 bp overlap

Motif DE_72h DE_72h-ZBTB18_MA0698.2 11 bp overlap

ZNF136 2 datasets

Motif DE_48h DE_48h-ZNF136_MA1588.1 15 bp overlap

Motif DE_60h DE_60h-ZNF136_MA1588.1 15 bp overlap

ZNF18 3 datasets

ChIP HEK293 ENCFF066NGR 275 bp overlap

ChIP HEK293 ENCSR977HTH.ZNF18.HEK293 390 bp overlap

ChIP HEK293 GSE76494.ZNF18.HEK293 227 bp overlap

ZNF24 3 datasets

ChIP K-562 ENCSR099NCH.ZNF24.K-562 216 bp overlap

ChIP K-562 ENCSR695EQB.ZNF24.K-562 145 bp overlap

ChIP K-562 ENCSR385AHH.ZNF24.K-562 549 bp overlap

ZNF410 1 dataset

Motif DE_48h DE_48h-ZNF410_MA0752.2 16 bp overlap

ZNF418 2 datasets

Motif DE_48h DE_48h-ZNF418_MA1980.1 15 bp overlap

Motif DE_60h DE_60h-ZNF418_MA1980.1 15 bp overlap

ZNF524 1 dataset

Motif DE_48h DE_48h-ZNF524_MA2096.1 9 bp overlap

ZNF547 2 datasets

Motif DE_48h DE_48h-ZNF547_MA2334.1 13 bp overlap

Motif DE_60h DE_60h-ZNF547_MA2334.1 13 bp overlap

ZNF667 2 datasets

Motif DE_48h DE_48h-ZNF667_MA1984.2 11 bp overlap

Motif DE_60h DE_60h-ZNF667_MA1984.2 11 bp overlap

ZNF707 3 datasets

Motif DE_48h DE_48h-ZNF707_MA1715.1 15 bp overlap

Motif DE_60h DE_60h-ZNF707_MA1715.1 15 bp overlap

Motif DE_72h DE_72h-ZNF707_MA1715.1 15 bp overlap

Motif DE_48h DE_48h-ZNF8_MA1718.1 20 bp overlap

ZSCAN5C 2 datasets

ChIP HEK293 ENCFF343DTU 169 bp overlap

ChIP HEK293 ENCSR731AGO.ZSCAN5C.HEK293 302 bp overlap