Enables identical protein binding activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MPC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:167,713,429–167,715,919 | 220.4 kb | Distal (>10kb) Multiome | 1144 | |
| chr1:167,716,321–167,716,922 | 219.4 kb | Distal (>10kb) Multiome | 279 | |
| chr1:167,721,587–167,722,654 | 214.1 kb | Distal (>10kb) Multiome HiCAR | 729 | |
| chr1:167,735,321–167,736,296 | 200.2 kb | Distal (>10kb) Multiome | 106 | |
| chr1:167,791,182–167,791,821 | 144.5 kb | Distal (>10kb) Multiome | 97 | |
| chr1:167,803,184–167,803,921 | 132.6 kb | Distal (>10kb) Multiome | 643 | |
| chr1:167,819,954–167,820,473 | 115.7 kb | Distal (>10kb) Multiome | 410 | |
| chr1:167,822,319–167,822,995 | 113.4 kb | Distal (>10kb) Multiome | 107 | |
| chr1:167,856,829–167,857,439 | 78.8 kb | Distal (>10kb) Multiome | 62 | |
| chr1:167,935,207–167,937,689 | 300 bp | At TSS Multiome | 1086 | |
| chr1:168,082,150–168,082,782 | 146.4 kb | Distal (>10kb) Multiome | 282 | |
| chr1:168,135,686–168,137,665 | 200.9 kb | Distal (>10kb) Multiome | 557 | |
| chr1:168,145,525–168,146,368 | 209.9 kb | Distal (>10kb) Multiome | 327 | |
| chr1:168,146,489–168,147,203 | 210.9 kb | Distal (>10kb) Multiome | 155 | |
| chr1:168,178,414–168,179,583 | 242.9 kb | Distal (>10kb) Multiome | 940 | |
| chr1:168,187,044–168,187,988 | 251.4 kb | Distal (>10kb) Multiome | 107 | |
| chr1:168,225,447–168,226,729 | 289.9 kb | Distal (>10kb) Multiome | 1005 |
Genomic view of the MPC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.