The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for DCAF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:167,713,429–167,715,919 | 221.1 kb | Distal (>10kb) Multiome | 1144 | |
| chr1:167,716,321–167,716,922 | 220.1 kb | Distal (>10kb) Multiome | 279 | |
| chr1:167,721,587–167,722,654 | 214.7 kb | Distal (>10kb) Multiome HiCAR | 729 | |
| chr1:167,735,321–167,736,296 | 200.8 kb | Distal (>10kb) Multiome | 106 | |
| chr1:167,791,182–167,791,821 | 145.1 kb | Distal (>10kb) Multiome | 97 | |
| chr1:167,803,184–167,803,921 | 133.2 kb | Distal (>10kb) Multiome | 643 | |
| chr1:167,819,954–167,820,473 | 116.4 kb | Distal (>10kb) Multiome | 410 | |
| chr1:167,822,319–167,822,995 | 114.0 kb | Distal (>10kb) Multiome | 107 | |
| chr1:167,856,829–167,857,439 | 79.4 kb | Distal (>10kb) Multiome | 62 | |
| chr1:167,935,207–167,937,689 | 320 bp | At TSS Multiome | 1086 | |
| chr1:168,082,150–168,082,782 | 145.8 kb | Distal (>10kb) Multiome | 282 | |
| chr1:168,135,686–168,137,665 | 200.2 kb | Distal (>10kb) Multiome | 557 | |
| chr1:168,145,525–168,146,368 | 209.3 kb | Distal (>10kb) Multiome | 327 | |
| chr1:168,146,489–168,147,203 | 210.2 kb | Distal (>10kb) Multiome | 155 | |
| chr1:168,178,414–168,179,583 | 242.2 kb | Distal (>10kb) Multiome | 940 | |
| chr1:168,187,044–168,187,988 | 250.8 kb | Distal (>10kb) Multiome | 107 | |
| chr1:168,225,447–168,226,729 | 289.3 kb | Distal (>10kb) Multiome | 1005 |
Genomic view of the DCAF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.