Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for SOX12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOX12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOX12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:266,689–267,291 | 58.5 kb | Distal (>10kb) Multiome | 931 | |
| chr20:290,009–290,864 | 35.0 kb | Distal (>10kb) Multiome | 706 | |
| chr20:297,159–298,781 | 28.1 kb | Distal (>10kb) Multiome | 1084 | |
| chr20:300,984–301,434 | 24.3 kb | Distal (>10kb) Multiome | 252 | |
| chr20:309,597–310,812 | 15.0 kb | Distal (>10kb) Multiome | 589 | |
| chr20:323,634–328,069 | 1.7 kb | Proximal (<10kb) Multiome | 1260 | |
| chr20:330,299–330,873 | 5.1 kb | Proximal (<10kb) Multiome | 376 | |
| chr20:346,592–348,332 | 22.4 kb | Distal (>10kb) Multiome | 1061 | |
| chr20:354,335–354,944 | 29.1 kb | Distal (>10kb) Multiome | 631 | |
| chr20:380,569–381,493 | 55.4 kb | Distal (>10kb) Multiome | 958 | |
| chr20:381,625–382,263 | 56.5 kb | Distal (>10kb) Multiome | 745 | |
| chr20:407,136–409,109 | 82.5 kb | Distal (>10kb) Multiome | 1064 | |
| chr20:461,861–463,102 | 137.0 kb | Distal (>10kb) Multiome | 871 | |
| chr20:543,069–544,398 | 218.3 kb | Distal (>10kb) Multiome | 965 | |
| chr20:555,914–556,523 | 230.6 kb | Distal (>10kb) Multiome | 249 | |
| chr20:574,398–574,909 | 249.1 kb | Distal (>10kb) Multiome | 119 | |
| chr20:609,984–610,596 | 284.8 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the SOX12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.