TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for TIPRL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIPRL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIPRL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:167,935,207–167,937,689 | 242.6 kb | Distal (>10kb) Multiome | 1086 | |
| chr1:168,082,150–168,082,782 | 96.5 kb | Distal (>10kb) Multiome | 282 | |
| chr1:168,135,686–168,137,665 | 42.1 kb | Distal (>10kb) Multiome | 557 | |
| chr1:168,145,525–168,146,368 | 33.0 kb | Distal (>10kb) Multiome | 327 | |
| chr1:168,146,489–168,147,203 | 32.1 kb | Distal (>10kb) Multiome | 155 | |
| chr1:168,178,414–168,179,583 | 56 bp | At TSS Multiome | 940 | |
| chr1:168,187,044–168,187,988 | 8.5 kb | Proximal (<10kb) Multiome | 107 | |
| chr1:168,225,447–168,226,729 | 47.0 kb | Distal (>10kb) Multiome | 1005 | |
| chr1:169,485,050–169,486,633 | 1307.0 kb | Distal (>10kb) Multiome HiCAR | 1015 |
Genomic view of the TIPRL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.