ADCY10

ADCY10

adenylate cyclase 10 | HCA2, RP1-313L4.2, SAC, SACI, Sacy

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

Developmental clusters: GC6

Biological processes 74 terms

ATPase binding (GO:0051117)adenylate cyclase activity (GO:0004016)adenylate cyclase activity (GO:0004016)adenylate cyclase activity (GO:0004016)adenylate cyclase activity (GO:0004016)adenylate cyclase activity (GO:0004016)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (GO:0007193)apical part of cell (GO:0045177)astrocyte end-foot (GO:0097450)axon (GO:0030424)basal part of cell (GO:0045178)bicarbonate binding (GO:0071890)cAMP biosynthetic process (GO:0006171)cAMP biosynthetic process (GO:0006171)cAMP biosynthetic process (GO:0006171)cellular response to carbon dioxide (GO:0071244)cellular response to carbon dioxide (GO:0071244)central region of growth cone (GO:0090724)cilium (GO:0005929)cyclic nucleotide biosynthetic process (GO:0009190)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)dendrite (GO:0030425)epithelial cilium movement involved in extracellular fluid movement (GO:0003351)extracellular region (GO:0005576)glucose catabolic process (GO:0006007)growth cone (GO:0030426)intracellular signal transduction (GO:0035556)magnesium ion binding (GO:0000287)manganese ion binding (GO:0030145)microtubule cytoskeleton (GO:0015630)mitochondrial ATP transmembrane transport (GO:1990544)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)molecular sensor activity (GO:0140299)molecular sensor activity (GO:0140299)motile cilium (GO:0031514)negative regulation of cardiac muscle cell contraction (GO:0106135)negative regulation of mitochondrial membrane potential (GO:0010917)negative regulation of reactive oxygen species biosynthetic process (GO:1903427)neuron projection extension (GO:1990138)neuron projection maintenance (GO:1990535)neuron projection retraction (GO:0106028)neuronal cell body (GO:0043025)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)positive regulation of ATP biosynthetic process (GO:2001171)positive regulation of apoptotic process (GO:0043065)positive regulation of axon extension (GO:0045773)positive regulation of cardiac muscle cell apoptotic process (GO:0010666)positive regulation of cardiac muscle hypertrophy (GO:0010613)positive regulation of glycogen catabolic process (GO:0045819)positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)positive regulation of mitochondrial depolarization (GO:0051901)positive regulation of ossification (GO:0045778)positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (GO:1903378)positive regulation of protein localization to mitochondrion (GO:1903749)positive regulation of reactive oxygen species biosynthetic process (GO:1903428)positive regulation of vascular associated smooth muscle cell apoptotic process (GO:1905461)regulation of intracellular pH (GO:0051453)regulation of intracellular pH (GO:0051453)regulation of membrane repolarization (GO:0060306)regulation of mitophagy (GO:1901524)spermatid development (GO:0007286)spermatogenesis (GO:0007283)

Expression (TPM)

TFs regulating ADCY10 0 TFs

Transcription factors with Perturb-seq knockdown data for ADCY10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCY10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ADCY10

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCY10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr1:167,713,429–167,715,919	198.6 kb	Distal (>10kb) Multiome	1144
	chr1:167,716,321–167,716,922	197.6 kb	Distal (>10kb) Multiome	279
	chr1:167,721,587–167,722,654	192.3 kb	Distal (>10kb) Multiome	729
	chr1:167,735,321–167,736,296	178.3 kb	Distal (>10kb) Multiome	106
	chr1:167,791,182–167,791,821	122.7 kb	Distal (>10kb) Multiome	97
	chr1:167,803,184–167,803,921	110.7 kb	Distal (>10kb) Multiome	643
	chr1:167,819,954–167,820,473	93.9 kb	Distal (>10kb) Multiome	410
	chr1:167,822,319–167,822,995	91.5 kb	Distal (>10kb) Multiome	107
	chr1:167,856,829–167,857,439	57.0 kb	Distal (>10kb) Multiome	62
	chr1:167,912,287–167,912,630	1.6 kb	Proximal (<10kb)	68
	chr1:167,935,207–167,937,689	22.1 kb	Distal (>10kb) Multiome	1086
	chr1:168,135,686–168,137,665	222.7 kb	Distal (>10kb) Multiome	557
	chr1:168,145,525–168,146,368	231.7 kb	Distal (>10kb) Multiome	327
	chr1:168,146,489–168,147,203	232.7 kb	Distal (>10kb) Multiome	155
	chr1:168,178,414–168,179,583	264.7 kb	Distal (>10kb) Multiome	940
	chr1:168,187,044–168,187,988	273.3 kb	Distal (>10kb) Multiome	107

Genome Browser

Genomic view of the ADCY10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.