The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for GPR161. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR161 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR161, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:167,856,829–167,857,439 | 280.4 kb | Distal (>10kb) Multiome | 62 | |
| chr1:167,935,207–167,937,689 | 201.3 kb | Distal (>10kb) Multiome | 1086 | |
| chr1:168,082,150–168,082,782 | 55.2 kb | Distal (>10kb) Multiome | 282 | |
| chr1:168,135,686–168,137,665 | 771 bp | At TSS Multiome | 557 | |
| chr1:168,141,803–168,142,440 | 5.1 kb | Proximal (<10kb) | 33 | |
| chr1:168,145,525–168,146,368 | 8.3 kb | Proximal (<10kb) Multiome | 327 | |
| chr1:168,146,489–168,147,203 | 9.2 kb | Proximal (<10kb) Multiome | 155 | |
| chr1:168,178,414–168,179,583 | 41.2 kb | Distal (>10kb) Multiome | 940 | |
| chr1:168,187,044–168,187,988 | 49.8 kb | Distal (>10kb) Multiome | 107 | |
| chr1:168,225,447–168,226,729 | 88.3 kb | Distal (>10kb) Multiome | 1005 |
Genomic view of the GPR161 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.