ZNF418

zinc finger protein 418 | FLJ31551, KIAA1956

Enables DNA-binding transcription repressor activity. Predicted to be involved in microautophagy; regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of transcription by RNA polymerase II. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 13 terms

DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity (GO:0001217)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)microautophagy (GO:0016237)negative regulation of DNA-templated transcription (GO:0045892)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF418 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF418. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF418 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF418

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF418, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:57,681,556–57,682,393	253.4 kb	Distal (>10kb) Multiome	724
chr19:57,708,682–57,709,450	226.2 kb	Distal (>10kb) Multiome	199
chr19:57,727,326–57,727,941	207.8 kb	Distal (>10kb) Multiome	400
chr19:57,746,610–57,747,111	188.6 kb	Distal (>10kb) Multiome	625
chr19:57,769,422–57,770,058	165.7 kb	Distal (>10kb) Multiome	509
chr19:57,803,547–57,804,316	131.5 kb	Distal (>10kb) Multiome	206
chr19:57,804,773–57,805,214	130.3 kb	Distal (>10kb) Multiome	37
chr19:57,810,480–57,811,177	124.6 kb	Distal (>10kb) Multiome	180
chr19:57,814,439–57,815,270	120.4 kb	Distal (>10kb) Multiome	692
chr19:57,819,268–57,819,991	115.7 kb	Distal (>10kb) Multiome	734
chr19:57,829,187–57,830,712	105.1 kb	Distal (>10kb) Multiome	321
chr19:57,849,421–57,850,221	85.6 kb	Distal (>10kb) Multiome	291
chr19:57,887,264–57,887,897	47.8 kb	Distal (>10kb) Multiome	47
chr19:57,888,389–57,889,457	46.3 kb	Distal (>10kb) Multiome	322
chr19:57,916,199–57,917,124	18.7 kb	Distal (>10kb) Multiome	535
chr19:57,934,907–57,935,617	27 bp	At TSS Multiome	259
chr19:57,947,388–57,948,012	12.4 kb	Distal (>10kb) Multiome	675
chr19:58,002,336–58,003,368	67.4 kb	Distal (>10kb) Multiome	830
chr19:58,059,066–58,059,937	124.0 kb	Distal (>10kb) Multiome	284
chr19:58,097,783–58,098,870	162.9 kb	Distal (>10kb) Multiome	458
chr19:58,150,278–58,150,941	215.3 kb	Distal (>10kb) Multiome HiCAR	533
chr19:58,154,448–58,155,527	219.7 kb	Distal (>10kb) Multiome HiCAR	802
chr19:58,182,544–58,183,906	247.8 kb	Distal (>10kb) Multiome	1019
chr19:58,228,362–58,229,199	293.5 kb	Distal (>10kb) Multiome	706

Genome Browser

Genomic view of the ZNF418 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.