chr4:6,182,458–6,183,222

chr4 : 6,182,458 – 6,183,222

764 bp 84 TFs 6 linked genes

This 764 bp open chromatin element is linked to 6 target genes and is bound by 84 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
C4orf50		17.8 kb	Distal	Multiome
JAKMIP1		17.8 kb	Distal	Multiome
ENSG00000290803		18.0 kb	Distal	Multiome
ENSG00000251408		19.6 kb	Distal	Multiome
WFS1		87.1 kb	Distal	Multiome
CRMP1		294.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

84 transcription factors

ChIP H-1_DE GSE126661.BRD3.H-1_DE 332 bp overlap

BRD4 3 datasets

ChIP Jurkat GSE83777.BRD4.Jurkat 304 bp overlap

ChIP KOPT-K1 GSE54379.BRD4.KOPT-K1 764 bp overlap

ChIP KOPT-K1_E GSE54379.BRD4.KOPT-K1_E 255 bp overlap

CBFB 2 datasets

ChIP GM12878 ENCFF056JUS 491 bp overlap

ChIP GM12878 ENCFF056JUS 340 bp overlap

CREB1 4 datasets

Motif DE_36h DE_36h-CREB1_MA0018.5 8 bp overlap

Motif DE_48h DE_48h-CREB1_MA0018.5 8 bp overlap

Motif DE_60h DE_60h-CREB1_MA0018.5 8 bp overlap

Motif DE_72h DE_72h-CREB1_MA0018.5 8 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF031ISE 471 bp overlap

ChIP GM12878 ENCSR000BMB.ELF1.GM12878 148 bp overlap

EOMES 5 datasets

Motif DE_36h DE_36h-EOMES_MA0800.2 9 bp overlap

Motif DE_48h DE_48h-EOMES_MA0800.2 9 bp overlap

Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap

Motif DE_72h DE_72h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 364 bp overlap

EP300 2 datasets

ChIP SK-N-SH ENCFF829RWA 377 bp overlap

ChIP SK-N-SH ENCSR000EHV.EP300.SK-N-SH 134 bp overlap

ESRRG 1 dataset

ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 195 bp overlap

ETV2::HOXB13 4 datasets

Motif DE_36h DE_36h-ETV2HOXB13_MA1943.2 13 bp overlap

Motif DE_48h DE_48h-ETV2HOXB13_MA1943.2 13 bp overlap

Motif DE_60h DE_60h-ETV2HOXB13_MA1943.2 13 bp overlap

Motif DE_72h DE_72h-ETV2HOXB13_MA1943.2 13 bp overlap

ETV5::FOXO1 4 datasets

Motif DE_36h DE_36h-ETV5FOXO1_MA1947.2 10 bp overlap

Motif DE_48h DE_48h-ETV5FOXO1_MA1947.2 10 bp overlap

Motif DE_60h DE_60h-ETV5FOXO1_MA1947.2 10 bp overlap

Motif DE_72h DE_72h-ETV5FOXO1_MA1947.2 10 bp overlap

EZH2 3 datasets

ChIP SU-DHL-5 GSE45982.EZH2.SU-DHL-5 64 bp overlap

ChIP THP-1 GSE135024.EZH2.THP-1 253 bp overlap

ChIP THP-1 GSE135024.EZH2.THP-1 118 bp overlap

FERD3L 4 datasets

Motif DE_36h DE_36h-FERD3L_MA1485.1 14 bp overlap

Motif DE_48h DE_48h-FERD3L_MA1485.1 14 bp overlap

Motif DE_60h DE_60h-FERD3L_MA1485.1 14 bp overlap

Motif DE_72h DE_72h-FERD3L_MA1485.1 14 bp overlap

FEZF2 1 dataset

Motif DE_48h DE_48h-FEZF2_MA2341.1 8 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 451 bp overlap

ChIP DE DE-FOXA2-2 660 bp overlap

GATA1 1 dataset

ChIP CD34_Day7_30min GSE104676.GATA1.CD34_Day7_30min 55 bp overlap

GATA2 6 datasets

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

ChIP SK-N-SH ENCFF764OZD 417 bp overlap

ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 144 bp overlap

GATA3 3 datasets

ChIP Jurkat GSE29180.GATA3.Jurkat 404 bp overlap

ChIP Jurkat GSE76181.GATA3.Jurkat 247 bp overlap

ChIP Jurkat GSE120063.GATA3.Jurkat 224 bp overlap

GATA4 7 datasets

ChIP DE DE-GATA4-1 693 bp overlap

ChIP DE DE-GATA4-2 764 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 575 bp overlap

GATA5 4 datasets

Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 15 datasets

ChIP DE DE-GATA6-1 718 bp overlap

ChIP DE DE-GATA6-2 764 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 608 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 715 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 702 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 764 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 703 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 669 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 725 bp overlap

ChIP foregut GSE117136.GATA6.foregut 695 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 469 bp overlap

Gata3 4 datasets

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HAND2 2 datasets

ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 302 bp overlap

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 176 bp overlap

HDGF 2 datasets

ChIP GM12878 ENCFF653WYI 385 bp overlap

ChIP GM12878 ENCFF653WYI 184 bp overlap

IRF4 4 datasets

Motif DE_36h DE_36h-IRF4_MA1419.2 14 bp overlap

Motif DE_48h DE_48h-IRF4_MA1419.2 14 bp overlap

Motif DE_60h DE_60h-IRF4_MA1419.2 14 bp overlap

Motif DE_72h DE_72h-IRF4_MA1419.2 14 bp overlap

IRF5 4 datasets

Motif DE_36h DE_36h-IRF5_MA1420.1 14 bp overlap

Motif DE_48h DE_48h-IRF5_MA1420.1 14 bp overlap

Motif DE_60h DE_60h-IRF5_MA1420.1 14 bp overlap

Motif DE_72h DE_72h-IRF5_MA1420.1 14 bp overlap

IRF6 4 datasets

Motif DE_36h DE_36h-IRF6_MA1509.1 9 bp overlap

Motif DE_48h DE_48h-IRF6_MA1509.1 9 bp overlap

Motif DE_60h DE_60h-IRF6_MA1509.1 9 bp overlap

Motif DE_72h DE_72h-IRF6_MA1509.1 9 bp overlap

IRF8 4 datasets

Motif DE_36h DE_36h-IRF8_MA0652.2 13 bp overlap

Motif DE_48h DE_48h-IRF8_MA0652.2 13 bp overlap

Motif DE_60h DE_60h-IRF8_MA0652.2 13 bp overlap

Motif DE_72h DE_72h-IRF8_MA0652.2 13 bp overlap

IRF9 4 datasets

Motif DE_36h DE_36h-IRF9_MA0653.1 15 bp overlap

Motif DE_48h DE_48h-IRF9_MA0653.1 15 bp overlap

Motif DE_60h DE_60h-IRF9_MA0653.1 15 bp overlap

Motif DE_72h DE_72h-IRF9_MA0653.1 15 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 433 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 447 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 419 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 660 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 573 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 456 bp overlap

ChIP Karpas-299 GSE151413.JUN.Karpas-299 732 bp overlap

ChIP Karpas-299 GSE151413.JUNB.Karpas-299 410 bp overlap

ChIP Jurkat GSE94391.LMO1.Jurkat 202 bp overlap

MEIS1 8 datasets

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MXI1 4 datasets

Motif DE_36h DE_36h-MXI1_MA1108.3 6 bp overlap

Motif DE_48h DE_48h-MXI1_MA1108.3 6 bp overlap

Motif DE_60h DE_60h-MXI1_MA1108.3 6 bp overlap

Motif DE_72h DE_72h-MXI1_MA1108.3 6 bp overlap

Motif DE_36h DE_36h-MYB_MA0100.4 6 bp overlap

ChIP Jurkat GSE59657.MYB.Jurkat 404 bp overlap

ChIP MOLT-3 GSE59657.MYB.MOLT-3 291 bp overlap

ChIP PF-382 GSE94000.MYB.PF-382 209 bp overlap

ChIP LA-N-5 GSE138295.MYCN.LA-N-5 229 bp overlap

Msgn1 2 datasets

Motif DE_36h DE_36h-Msgn1_MA1524.3 10 bp overlap

Motif DE_48h DE_48h-Msgn1_MA1524.3 10 bp overlap

NCOA2 1 dataset

ChIP MCF-7_E2 ERP000901.NCOA2.MCF-7_E2 118 bp overlap

NFKB1 1 dataset

ChIP L1236 GSE63736.NFKB1.L1236 118 bp overlap

NOTCH1 1 dataset

ChIP HPBALL GSE39263.NOTCH1.HPBALL 328 bp overlap

NR3C1 1 dataset

ChIP A-549 ENCSR000BJR.NR3C1.A-549 115 bp overlap

Nr2e3 1 dataset

Motif DE_48h DE_48h-Nr2e3_MA0164.2 6 bp overlap

Motif DE_48h DE_48h-OSR1_MA1542.2 8 bp overlap

Motif DE_48h DE_48h-OSR2_MA1646.2 8 bp overlap

PBX3 4 datasets

Motif DE_36h DE_36h-PBX3_MA1114.2 11 bp overlap

Motif DE_48h DE_48h-PBX3_MA1114.2 11 bp overlap

Motif DE_60h DE_60h-PBX3_MA1114.2 11 bp overlap

Motif DE_72h DE_72h-PBX3_MA1114.2 11 bp overlap

PKNOX1 4 datasets

Motif DE_36h DE_36h-PKNOX1_MA0782.3 10 bp overlap

Motif DE_48h DE_48h-PKNOX1_MA0782.3 10 bp overlap

Motif DE_60h DE_60h-PKNOX1_MA0782.3 10 bp overlap

Motif DE_72h DE_72h-PKNOX1_MA0782.3 10 bp overlap

Prdm4 4 datasets

Motif DE_36h DE_36h-Prdm4_MA1647.3 11 bp overlap

Motif DE_48h DE_48h-Prdm4_MA1647.3 11 bp overlap

Motif DE_60h DE_60h-Prdm4_MA1647.3 11 bp overlap

Motif DE_72h DE_72h-Prdm4_MA1647.3 11 bp overlap

RARA::RXRG 1 dataset

Motif DE_36h DE_36h-RARARXRG_MA1149.2 17 bp overlap

Motif DE_36h DE_36h-RFX4_MA0799.3 13 bp overlap

RUNX1 2 datasets

ChIP Jurkat GSE68976.RUNX1.Jurkat 213 bp overlap

ChIP Jurkat GSE68976.RUNX1.Jurkat 190 bp overlap

SMAD2 2 datasets

Motif DE_36h DE_36h-SMAD2_MA1964.2 6 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 310 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 764 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 610 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 527 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 492 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 575 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 548 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 764 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 764 bp overlap

SMAD3 2 datasets

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 148 bp overlap

ChIP endoderm GSE29422.SMAD3.endoderm 278 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 322 bp overlap

SMARCA4 2 datasets

ChIP J-Lat_GFP-Clone-A72_DMSO GSE100266.SMARCA4.J-Lat_GFP-Clone-A72_DMSO 320 bp overlap

ChIP NGP GSE134626.SMARCA4.NGP 238 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S15-DE-d1-BAF155-exp1 397 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 379 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 724 bp overlap

SREBF1 4 datasets

Motif DE_36h DE_36h-SREBF1_MA0829.3 10 bp overlap

Motif DE_48h DE_48h-SREBF1_MA0829.3 10 bp overlap

Motif DE_60h DE_60h-SREBF1_MA0829.3 10 bp overlap

Motif DE_72h DE_72h-SREBF1_MA0829.3 10 bp overlap

SREBF2 4 datasets

Motif DE_36h DE_36h-SREBF2_MA0596.1 10 bp overlap

Motif DE_48h DE_48h-SREBF2_MA0596.1 10 bp overlap

Motif DE_60h DE_60h-SREBF2_MA0596.1 10 bp overlap

Motif DE_72h DE_72h-SREBF2_MA0596.1 10 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 342 bp overlap

ChIP MOLT-3 GSE59657.TAL1.MOLT-3 292 bp overlap

TBR1 4 datasets

Motif DE_36h DE_36h-TBR1_MA0802.2 9 bp overlap

Motif DE_48h DE_48h-TBR1_MA0802.2 9 bp overlap

Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap

Motif DE_72h DE_72h-TBR1_MA0802.2 9 bp overlap

TBX1 4 datasets

Motif DE_36h DE_36h-TBX1_MA0805.1 8 bp overlap

Motif DE_48h DE_48h-TBX1_MA0805.1 8 bp overlap

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

Motif DE_72h DE_72h-TBX1_MA0805.1 8 bp overlap

ChIP hiPSC GSE81585.TBX5.hiPSC 285 bp overlap

TFAP2B 1 dataset

ChIP SK-N-SH ENCFF869XXQ 441 bp overlap

ChIP breast-organoid GSE113909.TP63.breast-organoid 116 bp overlap

TRPS1 4 datasets

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ChIP ALL GSE145549.YY1.ALL 660 bp overlap

ZBTB18 4 datasets

Motif DE_36h DE_36h-ZBTB18_MA0698.2 11 bp overlap

Motif DE_48h DE_48h-ZBTB18_MA0698.2 11 bp overlap

Motif DE_60h DE_60h-ZBTB18_MA0698.2 11 bp overlap

Motif DE_72h DE_72h-ZBTB18_MA0698.2 11 bp overlap

ZBTB26 1 dataset

Motif DE_48h DE_48h-ZBTB26_MA1579.2 8 bp overlap

ZFP14 8 datasets

Motif DE_36h DE_36h-ZFP14_MA1972.1 15 bp overlap

Motif DE_36h DE_36h-ZFP14_MA1972.1 15 bp overlap

Motif DE_48h DE_48h-ZFP14_MA1972.1 15 bp overlap

Motif DE_48h DE_48h-ZFP14_MA1972.1 15 bp overlap

Motif DE_60h DE_60h-ZFP14_MA1972.1 15 bp overlap

Motif DE_60h DE_60h-ZFP14_MA1972.1 15 bp overlap

Motif DE_72h DE_72h-ZFP14_MA1972.1 15 bp overlap

Motif DE_72h DE_72h-ZFP14_MA1972.1 15 bp overlap

Motif DE_48h DE_48h-ZIM3_MA1709.2 11 bp overlap

ZKSCAN1 4 datasets

Motif DE_36h DE_36h-ZKSCAN1_MA1585.2 9 bp overlap

Motif DE_48h DE_48h-ZKSCAN1_MA1585.2 9 bp overlap

Motif DE_60h DE_60h-ZKSCAN1_MA1585.2 9 bp overlap

Motif DE_72h DE_72h-ZKSCAN1_MA1585.2 9 bp overlap

ZMIZ1 1 dataset

ChIP THP-6_shCtrl GSE138516.ZMIZ1.THP-6_shCtrl 286 bp overlap

ZNF143 1 dataset

ChIP Hep-G2 ENCSR080UEM.ZNF143.Hep-G2 203 bp overlap

ZNF16 4 datasets

Motif DE_36h DE_36h-ZNF16_MA1654.2 21 bp overlap

Motif DE_48h DE_48h-ZNF16_MA1654.2 21 bp overlap

Motif DE_60h DE_60h-ZNF16_MA1654.2 21 bp overlap

Motif DE_72h DE_72h-ZNF16_MA1654.2 21 bp overlap

ZNF317 1 dataset

Motif DE_48h DE_48h-ZNF317_MA1593.2 8 bp overlap

ZNF770 1 dataset

Motif DE_48h DE_48h-ZNF770_MA2099.1 8 bp overlap

ZSCAN4 4 datasets

Motif DE_36h DE_36h-ZSCAN4_MA1155.1 15 bp overlap

Motif DE_48h DE_48h-ZSCAN4_MA1155.1 15 bp overlap

Motif DE_60h DE_60h-ZSCAN4_MA1155.1 15 bp overlap

Motif DE_72h DE_72h-ZSCAN4_MA1155.1 15 bp overlap

Zic1::Zic2 4 datasets

Motif DE_36h DE_36h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_60h DE_60h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_72h DE_72h-Zic1Zic2_MA1628.2 7 bp overlap

Zic2 4 datasets

Motif DE_36h DE_36h-Zic2_MA1629.2 9 bp overlap

Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap

Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap

Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap

Zic3 4 datasets

Motif DE_36h DE_36h-Zic3_MA0697.3 7 bp overlap

Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap

Motif DE_60h DE_60h-Zic3_MA0697.3 7 bp overlap

Motif DE_72h DE_72h-Zic3_MA0697.3 7 bp overlap