This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for ZMIZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZMIZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZMIZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:78,438,167–78,439,059 | 630.5 kb | Distal (>10kb) Multiome HiCAR | 357 | |
| chr10:78,913,517–78,914,084 | 155.1 kb | Distal (>10kb) Multiome | 269 | |
| chr10:78,973,169–78,974,485 | 95.0 kb | Distal (>10kb) Multiome HiCAR | 1011 | |
| chr10:78,974,622–78,975,244 | 93.9 kb | Distal (>10kb) Multiome HiCAR | 574 | |
| chr10:79,027,324–79,028,383 | 41.1 kb | Distal (>10kb) Multiome | 344 | |
| chr10:79,059,142–79,059,755 | 9.5 kb | Proximal (<10kb) Multiome | 478 | |
| chr10:79,066,353–79,069,731 | 1.7 kb | Proximal (<10kb) Multiome | 956 | |
| chr10:79,069,906–79,071,537 | 941 bp | At TSS | 573 | |
| chr10:79,074,853–79,075,148 | 5.9 kb | Proximal (<10kb) | 67 | |
| chr10:79,093,590–79,094,392 | 24.9 kb | Distal (>10kb) Multiome | 583 | |
| chr10:79,129,088–79,129,986 | 60.5 kb | Distal (>10kb) Multiome | 462 | |
| chr10:79,157,212–79,158,222 | 88.8 kb | Distal (>10kb) Multiome | 633 | |
| chr10:79,195,004–79,195,734 | 126.6 kb | Distal (>10kb) Multiome | 517 | |
| chr10:79,239,374–79,240,591 | 171.4 kb | Distal (>10kb) Multiome | 318 | |
| chr10:79,242,182–79,244,115 | 174.5 kb | Distal (>10kb) Multiome | 517 | |
| chr10:79,344,555–79,345,573 | 275.9 kb | Distal (>10kb) Multiome | 144 | |
| chr10:79,346,612–79,348,513 | 278.4 kb | Distal (>10kb) Multiome | 939 |
Genomic view of the ZMIZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.