Enables sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transporter activity; positive regulation of gastrulation; and pronephros development. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for OSR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:19,347,544–19,348,931 | 9.7 kb | Proximal (<10kb) | 939 | |
| chr2:19,349,658–19,351,441 | 7.2 kb | Proximal (<10kb) | 369 | |
| chr2:19,351,547–19,352,361 | 6.3 kb | Proximal (<10kb) | 155 | |
| chr2:19,353,395–19,353,782 | 4.8 kb | Proximal (<10kb) | 48 | |
| chr2:19,355,692–19,359,423 | at TSS | At TSS | 616 | |
| chr2:19,359,785–19,359,983 | 1.2 kb | Proximal (<10kb) | 9 | |
| chr2:19,361,166–19,361,342 | 2.5 kb | Proximal (<10kb) | 40 | |
| chr2:19,361,453–19,361,928 | 2.8 kb | Proximal (<10kb) | 148 | |
| chr2:19,362,865–19,363,810 | 4.2 kb | Proximal (<10kb) | 568 |
Genomic view of the OSR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.