chr11:27,628,672–27,629,755

chr11 : 27,628,672 – 27,629,755

1,083 bp 92 TFs 6 linked genes

This 1.1 kb open chromatin element is linked to 6 target genes and is bound by 92 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
LINC00678		4.9 kb	Proximal	Proximity
BDNF		71.2 kb	Distal	Multiome
BDNF-AS		122.4 kb	Distal	Multiome
LIN7C		122.5 kb	Distal	Multiome
LGR4		156.5 kb	Distal	Multiome
CCDC34		266.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

92 transcription factors

ChIP WTC11 ENCFF267GQJ 241 bp overlap

ChIP WTC11 ENCFF267GQJ 317 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 134 bp overlap

Arid3b 1 dataset

Motif DE_12h DE_12h-Arid3b_MA0601.2 7 bp overlap

Atoh1 2 datasets

Motif DE_12h DE_12h-Atoh1_MA1467.3 7 bp overlap

Motif ES_0h ES_0h-Atoh1_MA1467.3 7 bp overlap

Bach1::Mafk 2 datasets

Motif DE_12h DE_12h-Bach1Mafk_MA0591.2 12 bp overlap

Motif ES_0h ES_0h-Bach1Mafk_MA0591.2 12 bp overlap

CEBPD 1 dataset

Motif DE_12h DE_12h-CEBPD_MA0836.3 8 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 288 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 132 bp overlap

CREB1 2 datasets

Motif DE_12h DE_12h-CREB1_MA0018.5 8 bp overlap

Motif DE_12h DE_12h-CREB1_MA0018.5 8 bp overlap

CTCF 3 datasets

Motif DE_12h DE_12h-CTCF_MA1930.2 33 bp overlap

Motif DE_24h DE_24h-CTCF_MA1930.2 33 bp overlap

Motif ES_0h ES_0h-CTCF_MA1930.2 33 bp overlap

Motif DE_12h DE_12h-DUX4_MA0468.1 11 bp overlap

E2F8 3 datasets

Motif DE_12h DE_12h-E2F8_MA0865.3 9 bp overlap

Motif DE_24h DE_24h-E2F8_MA0865.3 9 bp overlap

Motif ES_0h ES_0h-E2F8_MA0865.3 9 bp overlap

ChIP WTC11 ENCFF692RZJ 123 bp overlap

EWSR1-FLI1 1 dataset

Motif DE_12h DE_12h-EWSR1-FLI1_MA0149.1 18 bp overlap

Motif DE_12h DE_12h-FOS_MA1951.2 13 bp overlap

FOXD3 1 dataset

Motif DE_12h DE_12h-FOXD3_MA0041.3 14 bp overlap

GATA4 1 dataset

ChIP DE DE-GATA4-2 142 bp overlap

GATA6 3 datasets

ChIP DE DE-GATA6-2 153 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 583 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 507 bp overlap

HAND2 2 datasets

Motif DE_12h DE_12h-HAND2_MA1638.2 6 bp overlap

Motif ES_0h ES_0h-HAND2_MA1638.2 6 bp overlap

Motif DE_12h DE_12h-HIC2_MA0738.2 6 bp overlap

HOXB13 1 dataset

Motif DE_12h DE_12h-HOXB13_MA0901.3 9 bp overlap

Motif DE_12h DE_12h-Hmx2_MA0897.2 15 bp overlap

Motif DE_12h DE_12h-Hmx3_MA0898.2 9 bp overlap

Hoxa13 3 datasets

Motif DE_12h DE_12h-Hoxa13_MA0650.4 8 bp overlap

Motif DE_24h DE_24h-Hoxa13_MA0650.4 8 bp overlap

Motif ES_0h ES_0h-Hoxa13_MA0650.4 8 bp overlap

Motif DE_12h DE_12h-IRF2_MA0051.2 16 bp overlap

Motif DE_12h DE_12h-IRF3_MA1418.2 17 bp overlap

Motif DE_12h DE_12h-ISL2_MA0914.2 6 bp overlap

Motif DE_12h DE_12h-JUN_MA0488.2 10 bp overlap

Motif DE_12h DE_12h-JUN_MA0488.2 10 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 277 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 493 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 455 bp overlap

KLF1 3 datasets

Motif DE_12h DE_12h-KLF1_MA0493.3 8 bp overlap

Motif DE_24h DE_24h-KLF1_MA0493.3 8 bp overlap

Motif ES_0h ES_0h-KLF1_MA0493.3 8 bp overlap

KLF10 3 datasets

Motif DE_12h DE_12h-KLF10_MA1511.2 9 bp overlap

Motif DE_24h DE_24h-KLF10_MA1511.2 9 bp overlap

Motif ES_0h ES_0h-KLF10_MA1511.2 9 bp overlap

KLF13 3 datasets

Motif DE_12h DE_12h-KLF13_MA0657.2 17 bp overlap

Motif DE_24h DE_24h-KLF13_MA0657.2 17 bp overlap

Motif ES_0h ES_0h-KLF13_MA0657.2 17 bp overlap

KLF14 3 datasets

Motif DE_12h DE_12h-KLF14_MA0740.2 9 bp overlap

Motif DE_24h DE_24h-KLF14_MA0740.2 9 bp overlap

Motif ES_0h ES_0h-KLF14_MA0740.2 9 bp overlap

KLF16 3 datasets

Motif DE_12h DE_12h-KLF16_MA0741.1 11 bp overlap

Motif DE_24h DE_24h-KLF16_MA0741.1 11 bp overlap

Motif ES_0h ES_0h-KLF16_MA0741.1 11 bp overlap

KLF2 3 datasets

Motif DE_12h DE_12h-KLF2_MA1515.2 8 bp overlap

Motif DE_24h DE_24h-KLF2_MA1515.2 8 bp overlap

Motif ES_0h ES_0h-KLF2_MA1515.2 8 bp overlap

KLF4 3 datasets

Motif DE_12h DE_12h-KLF4_MA0039.5 8 bp overlap

Motif DE_24h DE_24h-KLF4_MA0039.5 8 bp overlap

Motif ES_0h ES_0h-KLF4_MA0039.5 8 bp overlap

KLF5 3 datasets

Motif DE_12h DE_12h-KLF5_MA0599.1 10 bp overlap

Motif DE_24h DE_24h-KLF5_MA0599.1 10 bp overlap

Motif ES_0h ES_0h-KLF5_MA0599.1 10 bp overlap

KLF9 3 datasets

Motif DE_12h DE_12h-KLF9_MA1107.3 11 bp overlap

Motif DE_24h DE_24h-KLF9_MA1107.3 11 bp overlap

Motif ES_0h ES_0h-KLF9_MA1107.3 11 bp overlap

MAFF 2 datasets

Motif DE_12h DE_12h-MAFF_MA0495.4 11 bp overlap

Motif DE_12h DE_12h-MAFF_MA0495.4 11 bp overlap

MAFK 2 datasets

Motif DE_12h DE_12h-MAFK_MA0496.4 10 bp overlap

Motif ES_0h ES_0h-MAFK_MA0496.4 10 bp overlap

MEF2B 4 datasets

Motif DE_12h DE_12h-MEF2B_MA0660.1 12 bp overlap

Motif DE_12h DE_12h-MEF2B_MA0660.1 12 bp overlap

Motif DE_24h DE_24h-MEF2B_MA0660.1 12 bp overlap

Motif ES_0h ES_0h-MEF2B_MA0660.1 12 bp overlap

MEF2D 4 datasets

Motif DE_12h DE_12h-MEF2D_MA0773.1 12 bp overlap

Motif DE_12h DE_12h-MEF2D_MA0773.1 12 bp overlap

Motif DE_24h DE_24h-MEF2D_MA0773.1 12 bp overlap

Motif ES_0h ES_0h-MEF2D_MA0773.1 12 bp overlap

MEIS1 3 datasets

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

MGA::EVX1 1 dataset

Motif DE_12h DE_12h-MGAEVX1_MA1960.2 11 bp overlap

Mafb 2 datasets

Motif DE_12h DE_12h-Mafb_MA0117.3 11 bp overlap

Motif DE_12h DE_12h-Mafb_MA0117.3 11 bp overlap

NANOG 5 datasets

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 298 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 437 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 231 bp overlap

NEUROD1 2 datasets

Motif DE_12h DE_12h-NEUROD1_MA1109.2 8 bp overlap

Motif ES_0h ES_0h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 2 datasets

Motif DE_12h DE_12h-NEUROG2_MA1642.2 7 bp overlap

Motif ES_0h ES_0h-NEUROG2_MA1642.2 7 bp overlap

Motif DE_12h DE_12h-NRL_MA0842.3 12 bp overlap

Motif DE_12h DE_12h-NRL_MA0842.3 12 bp overlap

Neurod2 2 datasets

Motif DE_12h DE_12h-Neurod2_MA0668.3 8 bp overlap

Motif ES_0h ES_0h-Neurod2_MA0668.3 8 bp overlap

Nkx3-2 1 dataset

Motif DE_12h DE_12h-Nkx3-2_MA0122.4 10 bp overlap

Nr1h3::Rxra 2 datasets

Motif DE_12h DE_12h-Nr1h3Rxra_MA0494.2 16 bp overlap

Motif ES_0h ES_0h-Nr1h3Rxra_MA0494.2 16 bp overlap

PATZ1 3 datasets

Motif DE_12h DE_12h-PATZ1_MA1961.2 11 bp overlap

Motif DE_24h DE_24h-PATZ1_MA1961.2 11 bp overlap

Motif ES_0h ES_0h-PATZ1_MA1961.2 11 bp overlap

POLR2A 5 datasets

ChIP GM23338 ENCFF450WCS 676 bp overlap

ChIP H1 ENCFF770YBQ 61 bp overlap

ChIP H1 ENCFF770YBQ 471 bp overlap

ChIP H1 ENCFF770YBQ 471 bp overlap

ChIP H1 ENCFF833NJP 370 bp overlap

POU5F1 1 dataset

ChIP GM23338 ENCFF333SNB 311 bp overlap

PPARG 3 datasets

Motif DE_12h DE_12h-PPARG_MA0066.2 19 bp overlap

Motif DE_24h DE_24h-PPARG_MA0066.2 19 bp overlap

Motif ES_0h ES_0h-PPARG_MA0066.2 19 bp overlap

PRRX2 1 dataset

ChIP WTC11 ENCFF107JGJ 223 bp overlap

Plagl1 3 datasets

Motif DE_12h DE_12h-Plagl1_MA1615.2 8 bp overlap

Motif DE_24h DE_24h-Plagl1_MA1615.2 8 bp overlap

Motif ES_0h ES_0h-Plagl1_MA1615.2 8 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 290 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 338 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 328 bp overlap

ChIP WTC11 ENCFF688PEU 501 bp overlap

Motif DE_12h DE_12h-SP3_MA0746.3 11 bp overlap

Motif DE_24h DE_24h-SP3_MA0746.3 11 bp overlap

Motif ES_0h ES_0h-SP3_MA0746.3 11 bp overlap

SPIB 3 datasets

Motif DE_12h DE_12h-SPIB_MA0081.3 13 bp overlap

Motif DE_12h DE_12h-SPIB_MA0081.3 13 bp overlap

Motif ES_0h ES_0h-SPIB_MA0081.3 13 bp overlap

SREBF1 2 datasets

Motif DE_12h DE_12h-SREBF1_MA0595.1 10 bp overlap

Motif ES_0h ES_0h-SREBF1_MA0595.1 10 bp overlap

STAT1::STAT2 1 dataset

Motif DE_12h DE_12h-STAT1STAT2_MA0517.2 13 bp overlap

Motif DE_12h DE_12h-TBP_MA0108.3 7 bp overlap

Motif DE_24h DE_24h-TBP_MA0108.3 7 bp overlap

Motif ES_0h ES_0h-TBP_MA0108.3 7 bp overlap

ChIP H1 ENCFF859IIO 377 bp overlap

TBX19 1 dataset

Motif DE_12h DE_12h-TBX19_MA0804.2 17 bp overlap

TEAD1 2 datasets

Motif DE_12h DE_12h-TEAD1_MA0090.4 9 bp overlap

Motif DE_12h DE_12h-TEAD1_MA0090.4 9 bp overlap

TEAD2 2 datasets

Motif DE_12h DE_12h-TEAD2_MA1121.2 7 bp overlap

Motif DE_12h DE_12h-TEAD2_MA1121.2 7 bp overlap

TEAD3 2 datasets

Motif DE_12h DE_12h-TEAD3_MA0808.1 8 bp overlap

Motif DE_12h DE_12h-TEAD3_MA0808.1 8 bp overlap

TEAD4 2 datasets

Motif DE_12h DE_12h-TEAD4_MA0809.3 8 bp overlap

Motif DE_12h DE_12h-TEAD4_MA0809.3 8 bp overlap

THAP1 1 dataset

Motif DE_12h DE_12h-THAP1_MA0597.3 8 bp overlap

TRIM28 1 dataset

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 226 bp overlap

TWIST1 2 datasets

Motif DE_12h DE_12h-TWIST1_MA1123.3 8 bp overlap

Motif ES_0h ES_0h-TWIST1_MA1123.3 8 bp overlap

VEZF1 3 datasets

Motif DE_12h DE_12h-VEZF1_MA1578.2 6 bp overlap

Motif DE_24h DE_24h-VEZF1_MA1578.2 6 bp overlap

Motif ES_0h ES_0h-VEZF1_MA1578.2 6 bp overlap

Motif DE_12h DE_12h-Wt1_MA1627.2 10 bp overlap

ZBTB43 1 dataset

ChIP WTC11 ENCFF058JUB 485 bp overlap

ZIC1 3 datasets

Motif DE_12h DE_12h-ZIC1_MA0696.1 14 bp overlap

Motif DE_24h DE_24h-ZIC1_MA0696.1 14 bp overlap

Motif ES_0h ES_0h-ZIC1_MA0696.1 14 bp overlap

ZIC4 3 datasets

Motif DE_12h DE_12h-ZIC4_MA0751.2 14 bp overlap

Motif DE_24h DE_24h-ZIC4_MA0751.2 14 bp overlap

Motif ES_0h ES_0h-ZIC4_MA0751.2 14 bp overlap

ZIC5 3 datasets

Motif DE_12h DE_12h-ZIC5_MA1584.2 15 bp overlap

Motif DE_24h DE_24h-ZIC5_MA1584.2 15 bp overlap

Motif ES_0h ES_0h-ZIC5_MA1584.2 15 bp overlap

ZMAT4 1 dataset

ChIP WTC11 ENCFF608UXZ 241 bp overlap

ZNF354A 1 dataset

Motif DE_12h DE_12h-ZNF354A_MA1978.2 20 bp overlap

ZNF416 2 datasets

Motif DE_12h DE_12h-ZNF416_MA1979.2 10 bp overlap

Motif ES_0h ES_0h-ZNF416_MA1979.2 10 bp overlap

ZNF449 2 datasets

Motif DE_12h DE_12h-ZNF449_MA1656.2 10 bp overlap

Motif ES_0h ES_0h-ZNF449_MA1656.2 10 bp overlap

ZNF454 1 dataset

Motif DE_12h DE_12h-ZNF454_MA1712.2 17 bp overlap

ZNF530 3 datasets

Motif DE_12h DE_12h-ZNF530_MA1981.2 14 bp overlap

Motif DE_24h DE_24h-ZNF530_MA1981.2 14 bp overlap

Motif ES_0h ES_0h-ZNF530_MA1981.2 14 bp overlap

ZNF558 1 dataset

Motif DE_12h DE_12h-ZNF558_MA2335.1 29 bp overlap

ZNF582 2 datasets

Motif DE_12h DE_12h-ZNF582_MA1983.2 19 bp overlap

Motif ES_0h ES_0h-ZNF582_MA1983.2 19 bp overlap

ZNF671 1 dataset

ChIP WTC11 ENCFF053HBV 215 bp overlap

ZNF680 1 dataset

Motif DE_12h DE_12h-ZNF680_MA1729.2 11 bp overlap

ZNF682 2 datasets

Motif DE_12h DE_12h-ZNF682_MA1599.2 11 bp overlap

Motif ES_0h ES_0h-ZNF682_MA1599.2 11 bp overlap

ZNF684 1 dataset

Motif DE_12h DE_12h-ZNF684_MA1600.2 14 bp overlap

ZNF707 3 datasets

Motif DE_12h DE_12h-ZNF707_MA1715.1 15 bp overlap

Motif DE_24h DE_24h-ZNF707_MA1715.1 15 bp overlap

Motif ES_0h ES_0h-ZNF707_MA1715.1 15 bp overlap

ZNF784 3 datasets

Motif DE_12h DE_12h-ZNF784_MA1717.2 8 bp overlap

Motif DE_24h DE_24h-ZNF784_MA1717.2 8 bp overlap

Motif ES_0h ES_0h-ZNF784_MA1717.2 8 bp overlap