LIN7C
lin-7 cell polarity scaffold C | FLJ11215, LIN-7-C, LIN-7C, MALS-3, VELI3

Enables L27 domain binding activity and cytoskeletal protein binding activity. Involved in morphogenesis of an epithelial sheet. Located in cell-cell junction; cytoplasm; and plasma membrane. Part of MPP7-DLG1-LIN7 complex. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 32 terms
L27 domain binding (GO:0097016)L27 domain binding (GO:0097016)MPP7-DLG1-LIN7 complex (GO:0097025)MPP7-DLG1-LIN7 complex (GO:0097025)PDZ domain binding (GO:0030165)anchoring junction (GO:0070161)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)bicellular tight junction (GO:0005923)cell-cell junction (GO:0005911)cell-cell junction (GO:0005911)cell-cell junction (GO:0005911)cytoplasm (GO:0005737)cytoskeletal protein binding (GO:0008092)glutamatergic synapse (GO:0098978)membrane (GO:0016020)morphogenesis of an epithelial sheet (GO:0002011)neurotransmitter secretion (GO:0007269)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)postsynaptic density membrane (GO:0098839)presynapse (GO:0098793)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein transport (GO:0015031)protein-macromolecule adaptor activity (GO:0030674)regulation of synaptic assembly at neuromuscular junction (GO:0008582)synapse (GO:0045202)synapse (GO:0045202)synapse (GO:0045202)synaptic vesicle transport (GO:0048489)
Expression (TPM)
LIN7C — as a Regulated Gene

TFs regulating LIN7C 0 TFs

Transcription factors with Perturb-seq knockdown data for LIN7C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIN7C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to LIN7C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIN7C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:26,935,672–26,936,561 570.5 kb Distal (>10kb) Multiome HiCAR 212
chr11:27,186,846–27,189,000 318.5 kb Distal (>10kb) Multiome HiCAR 303
chr11:27,248,576–27,249,774 257.5 kb Distal (>10kb) Multiome 209
chr11:27,281,350–27,282,333 224.9 kb Distal (>10kb) Multiome 322
chr11:27,304,430–27,305,242 202.1 kb Distal (>10kb) Multiome 124
chr11:27,362,704–27,363,814 143.5 kb Distal (>10kb) Multiome 933
chr11:27,443,724–27,444,393 62.8 kb Distal (>10kb) Multiome 91
chr11:27,444,522–27,445,324 61.7 kb Distal (>10kb) Multiome 199
chr11:27,471,035–27,473,509 33.9 kb Distal (>10kb) Multiome 780
chr11:27,499,199–27,499,417 7.4 kb Proximal (<10kb) 104
chr11:27,506,080–27,507,386 18 bp At TSS Multiome 861
chr11:27,628,672–27,629,755 122.5 kb Distal (>10kb) Multiome 92
chr11:27,634,338–27,635,109 128.0 kb Distal (>10kb) Multiome 115
chr11:27,698,739–27,701,728 192.4 kb Distal (>10kb) Multiome 518
chr11:27,718,043–27,719,845 212.0 kb Distal (>10kb) Multiome 477
chr11:27,721,736–27,723,344 216.0 kb Distal (>10kb) Multiome 381
chr11:27,795,831–27,797,062 289.8 kb Distal (>10kb) Multiome 361
chr11:28,922,252–28,923,991 1416.1 kb Distal (>10kb) Multiome HiCAR 261

Genome Browser

Genomic view of the LIN7C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:26,925,672 – 28,933,991
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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