KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for KLF13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLF13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLF13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:31,080,520–31,081,043 | 246.1 kb | Distal (>10kb) Multiome | 104 | |
| chr15:31,215,308–31,216,834 | 111.2 kb | Distal (>10kb) Multiome | 704 | |
| chr15:31,303,449–31,303,980 | 23.3 kb | Distal (>10kb) Multiome | 89 | |
| chr15:31,306,371–31,306,948 | 20.1 kb | Distal (>10kb) Multiome | 185 | |
| chr15:31,319,934–31,320,225 | 6.6 kb | Proximal (<10kb) | 25 | |
| chr15:31,325,483–31,328,709 | 1.3 kb | Proximal (<10kb) Multiome | 809 | |
| chr15:31,328,824–31,329,595 | 2.0 kb | Proximal (<10kb) | 222 | |
| chr15:31,365,690–31,366,135 | 39.2 kb | Distal (>10kb) Multiome | 278 | |
| chr15:31,390,612–31,391,090 | 1.8 kb | Proximal (<10kb) | 14 | |
| chr15:31,391,589–31,393,337 | at TSS | At TSS | 359 | |
| chr15:31,396,989–31,397,614 | 70.5 kb | Distal (>10kb) Multiome | 420 | |
| chr15:31,483,077–31,484,288 | 156.8 kb | Distal (>10kb) Multiome | 111 | |
| chr15:31,598,531–31,599,249 | 272.1 kb | Distal (>10kb) Multiome | 63 |
Genomic view of the KLF13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.