LGR4

leucine rich repeat containing G protein-coupled receptor 4 | GPR48

The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]

Member of: DE-9 DE-9.3 Developmental clusters: GC1

Biological processes 36 terms

G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor signaling pathway (GO:0007186)bone mineralization (GO:0030282)bone mineralization (GO:0030282)bone remodeling (GO:0046849)bone remodeling (GO:0046849)circadian regulation of gene expression (GO:0032922)circadian regulation of gene expression (GO:0032922)circadian rhythm (GO:0007623)membrane (GO:0016020)metanephric glomerulus development (GO:0072224)metanephric nephron tubule morphogenesis (GO:0072282)negative regulation of cold-induced thermogenesis (GO:0120163)negative regulation of cold-induced thermogenesis (GO:0120163)negative regulation of cytokine production (GO:0001818)negative regulation of cytokine production (GO:0001818)negative regulation of toll-like receptor signaling pathway (GO:0034122)negative regulation of toll-like receptor signaling pathway (GO:0034122)osteoblast differentiation (GO:0001649)osteoblast differentiation (GO:0001649)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of Wnt signaling pathway (GO:0030177)positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)positive regulation of canonical Wnt signaling pathway (GO:0090263)positive regulation of canonical Wnt signaling pathway (GO:0090263)positive regulation of canonical Wnt signaling pathway (GO:0090263)protein binding (GO:0005515)protein-hormone receptor activity (GO:0016500)spermatogenesis (GO:0007283)spermatogenesis (GO:0007283)transmembrane signaling receptor activity (GO:0004888)transmembrane signaling receptor activity (GO:0004888)

Expression (TPM)

TFs regulating LGR4 0 TFs

Transcription factors with Perturb-seq knockdown data for LGR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LGR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LGR4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LGR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:27,186,846–27,189,000	284.5 kb	Distal (>10kb) Multiome HiCAR	303
chr11:27,248,576–27,249,774	223.5 kb	Distal (>10kb) Multiome HiCAR	209
chr11:27,281,350–27,282,333	190.9 kb	Distal (>10kb) Multiome	322
chr11:27,304,430–27,305,242	168.1 kb	Distal (>10kb) Multiome	124
chr11:27,362,704–27,363,814	109.5 kb	Distal (>10kb) Multiome HiCAR	933
chr11:27,443,724–27,444,393	28.9 kb	Distal (>10kb) Multiome	91
chr11:27,444,522–27,445,324	27.7 kb	Distal (>10kb) Multiome	199
chr11:27,464,274–27,464,707	8.1 kb	Proximal (<10kb)	222
chr11:27,471,035–27,473,509	30 bp	At TSS Multiome	780
chr11:27,506,080–27,507,386	34.0 kb	Distal (>10kb) Multiome	861
chr11:27,628,672–27,629,755	156.5 kb	Distal (>10kb) Multiome	92
chr11:27,634,338–27,635,109	162.0 kb	Distal (>10kb) Multiome	115
chr11:27,698,739–27,701,728	226.3 kb	Distal (>10kb) Multiome	518
chr11:27,718,043–27,719,845	246.0 kb	Distal (>10kb) Multiome	477
chr11:27,721,736–27,723,344	250.0 kb	Distal (>10kb) Multiome	381

Genome Browser

Genomic view of the LGR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.