DE-7

Supermodule 388 genes

Endoplasmic reticulum and secretory pathway components

This module contains 389 genes, including HLA-B, APOA1, HLA-C, ALDH2, and IGFBP3, predominantly enriched for proteins localized to the endoplasmic reticulum lumen, transport vesicles, and the external plasma membrane. Knockdown of SOX11, SNAI1, ILF3, FOXA2, and HES1 activates this module. Knockdown of ARID1A, SMARCC1, ZIC3, CNBP, and GATA4 represses this module.

Notable genes: HLA-B APOA1 HLA-C ALDH2 IGFBP3 GJA1 CST3 SELENOP Top TFs: ARID1A SOX11 SNAI1 SMARCC1 ILF3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (9)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-7.1	94	HLA-B APOA1 ALDH2 IGFBP3 CST3
DE-7.2	34	CNR1 SLC16A1 SLC11A2 TRIB2 PHF6
DE-7.3	27	GJA1 FURIN SPRY2 HAS2 FZD4
DE-7.4	17	CYP2R1 RNF20 GOPC AGGF1 APIP
DE-7.5	15	HLA-C HDAC1 CTSL GSN ATP6AP2
DE-7.6	14	ITGA7 SDC3 RAB11FIP2 NEDD1 PTPRU
DE-7.7	12	TDP2 UFM1 SELENOF EIF2AK1 MPHOSPH8
DE-7.8	12	MBOAT7 MLST8 CIB2 EPN1 EMC10
DE-7.9	11	SERPING1 LTA4H BDH2 UROS OCIAD1

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).