Enables identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Involved in several processes, including L-methionine salvage from methylthioadenosine; protein homotetramerization; and pyroptotic inflammatory response. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for APIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:34,915,652–34,917,175 | 69 bp | At TSS Multiome | 945 | |
| chr11:35,138,620–35,139,940 | 223.0 kb | Distal (>10kb) Multiome | 444 | |
| chr11:35,151,753–35,153,158 | 236.1 kb | Distal (>10kb) Multiome | 365 | |
| chr11:35,330,237–35,331,541 | 414.5 kb | Distal (>10kb) Multiome HiCAR | 105 | |
| chr11:35,333,879–35,334,801 | 418.1 kb | Distal (>10kb) Multiome HiCAR | 225 | |
| chr11:35,402,638–35,403,312 | 486.6 kb | Distal (>10kb) Multiome HiCAR | 55 | |
| chr11:35,418,192–35,419,975 | 503.0 kb | Distal (>10kb) Multiome HiCAR | 384 |
Genomic view of the APIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.