This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for GOPC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOPC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOPC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:117,481,405–117,483,867 | 119.8 kb | Distal (>10kb) Multiome | 1094 | |
| chr6:117,552,410–117,553,719 | 49.6 kb | Distal (>10kb) Multiome | 173 | |
| chr6:117,601,873–117,603,119 | 73 bp | At TSS Multiome | 1002 | |
| chr6:117,605,275–117,605,507 | 2.8 kb | Proximal (<10kb) | 228 | |
| chr6:117,611,681–117,612,280 | 9.2 kb | Proximal (<10kb) | 22 | |
| chr6:117,674,767–117,676,565 | 72.9 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the GOPC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.