The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for ITGA7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGA7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGA7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:55,630,484–55,631,684 | 85.0 kb | Distal (>10kb) Multiome | 41 | |
| chr12:55,645,990–55,646,787 | 69.7 kb | Distal (>10kb) Multiome | 520 | |
| chr12:55,681,171–55,682,136 | 34.4 kb | Distal (>10kb) Multiome HiCAR | 647 | |
| chr12:55,707,276–55,708,500 | 8.1 kb | Proximal (<10kb) Multiome HiCAR | 372 | |
| chr12:55,715,733–55,716,775 | 218 bp | At TSS Multiome HiCAR | 929 | |
| chr12:55,721,046–55,721,445 | 5.0 kb | Proximal (<10kb) | 305 | |
| chr12:55,724,713–55,724,888 | 8.7 kb | Proximal (<10kb) | 167 | |
| chr12:55,727,952–55,730,453 | 13.6 kb | Distal (>10kb) Multiome HiCAR | 895 | |
| chr12:55,736,969–55,737,781 | 21.2 kb | Distal (>10kb) Multiome | 496 | |
| chr12:55,737,830–55,739,085 | 22.5 kb | Distal (>10kb) Multiome | 475 | |
| chr12:55,742,540–55,744,252 | 27.1 kb | Distal (>10kb) Multiome | 631 | |
| chr12:55,745,091–55,746,361 | 29.8 kb | Distal (>10kb) Multiome | 299 | |
| chr12:55,817,254–55,818,558 | 101.9 kb | Distal (>10kb) Multiome | 749 | |
| chr12:55,829,008–55,831,505 | 113.6 kb | Distal (>10kb) Multiome | 921 | |
| chr12:55,926,651–55,928,471 | 210.9 kb | Distal (>10kb) Multiome | 993 | |
| chr12:55,931,904–55,932,439 | 216.1 kb | Distal (>10kb) Multiome | 279 | |
| chr12:55,940,073–55,940,746 | 224.4 kb | Distal (>10kb) Multiome | 478 | |
| chr12:55,966,006–55,967,470 | 250.7 kb | Distal (>10kb) Multiome | 615 | |
| chr12:55,973,347–55,974,716 | 257.8 kb | Distal (>10kb) Multiome | 966 | |
| chr12:55,996,814–55,997,861 | 281.2 kb | Distal (>10kb) Multiome | 680 | |
| chr12:56,006,888–56,008,461 | 291.6 kb | Distal (>10kb) Multiome | 745 |
Genomic view of the ITGA7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.