The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]
Transcription factors with Perturb-seq knockdown data for SELENOF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SELENOF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SELENOF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:86,703,797–86,705,777 | 209.5 kb | Distal (>10kb) Multiome | 1030 | |
| chr1:86,755,319–86,756,660 | 158.1 kb | Distal (>10kb) Multiome | 183 | |
| chr1:86,823,769–86,824,525 | 90.1 kb | Distal (>10kb) Multiome | 408 | |
| chr1:86,913,509–86,916,034 | 397 bp | At TSS Multiome | 926 | |
| chr1:87,131,612–87,132,886 | 217.9 kb | Distal (>10kb) Multiome | 494 | |
| chr1:87,133,487–87,134,387 | 219.8 kb | Distal (>10kb) Multiome | 138 | |
| chr1:87,151,430–87,152,405 | 237.9 kb | Distal (>10kb) Multiome | 383 |
Genomic view of the SELENOF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.