This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, May 2020]
Transcription factors with Perturb-seq knockdown data for SERPING1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERPING1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERPING1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,310,924–57,312,111 | 286.1 kb | Distal (>10kb) Multiome | 620 | |
| chr11:57,323,847–57,325,914 | 272.7 kb | Distal (>10kb) Multiome | 790 | |
| chr11:57,335,065–57,336,267 | 261.9 kb | Distal (>10kb) Multiome | 689 | |
| chr11:57,345,508–57,346,149 | 251.9 kb | Distal (>10kb) Multiome | 241 | |
| chr11:57,349,624–57,350,269 | 247.7 kb | Distal (>10kb) Multiome | 357 | |
| chr11:57,426,113–57,427,448 | 170.6 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 140.2 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 137.1 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,480,236–57,481,014 | 117.2 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 114.5 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 104.0 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 97.9 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 83.2 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 66.8 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 29.6 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 419 bp | At TSS Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 40.5 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 47.3 kb | Distal (>10kb) Multiome | 237 | |
| chr11:57,646,682–57,652,802 | 52.2 kb | Distal (>10kb) Multiome | 580 | |
| chr11:57,656,843–57,658,231 | 59.9 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 70.1 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 114.6 kb | Distal (>10kb) Multiome | 857 | |
| chr11:57,740,872–57,742,140 | 143.7 kb | Distal (>10kb) Multiome | 973 | |
| chr11:57,761,276–57,762,144 | 164.1 kb | Distal (>10kb) Multiome | 612 | |
| chr11:57,778,066–57,779,000 | 181.0 kb | Distal (>10kb) Multiome | 688 | |
| chr11:57,780,962–57,781,951 | 184.0 kb | Distal (>10kb) Multiome | 317 | |
| chr11:57,800,273–57,801,159 | 203.1 kb | Distal (>10kb) Multiome | 547 |
Genomic view of the SERPING1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.