The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for SDC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:29,249,179–29,249,843 | 1659.4 kb | Distal (>10kb) Multiome HiCAR | 238 | |
| chr1:29,259,283–29,260,756 | 1648.7 kb | Distal (>10kb) Multiome HiCAR | 310 | |
| chr1:29,282,701–29,284,079 | 1625.5 kb | Distal (>10kb) Multiome HiCAR | 308 | |
| chr1:30,638,708–30,639,350 | 269.7 kb | Distal (>10kb) Multiome | 35 | |
| chr1:30,685,020–30,686,083 | 223.3 kb | Distal (>10kb) Multiome | 317 | |
| chr1:30,690,022–30,690,694 | 218.4 kb | Distal (>10kb) Multiome | 35 | |
| chr1:30,717,727–30,719,875 | 190.4 kb | Distal (>10kb) Multiome HiCAR | 1003 | |
| chr1:30,782,240–30,782,828 | 126.2 kb | Distal (>10kb) Multiome HiCAR | 279 | |
| chr1:30,801,625–30,802,230 | 106.8 kb | Distal (>10kb) Multiome HiCAR | 372 | |
| chr1:30,824,074–30,824,916 | 84.2 kb | Distal (>10kb) Multiome | 678 | |
| chr1:30,837,666–30,838,184 | 70.9 kb | Distal (>10kb) Multiome HiCAR | 67 | |
| chr1:30,908,653–30,909,448 | 72 bp | At TSS Multiome | 272 | |
| chr1:30,911,228–30,911,813 | 2.5 kb | Proximal (<10kb) | 336 | |
| chr1:31,065,191–31,066,200 | 157.0 kb | Distal (>10kb) Multiome | 984 | |
| chr1:31,072,313–31,072,760 | 163.9 kb | Distal (>10kb) Multiome | 160 | |
| chr1:31,154,613–31,155,769 | 246.3 kb | Distal (>10kb) Multiome | 807 | |
| chr1:31,162,718–31,163,222 | 254.1 kb | Distal (>10kb) Multiome | 461 | |
| chr1:31,182,154–31,182,689 | 273.6 kb | Distal (>10kb) Multiome | 644 |
Genomic view of the SDC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.