This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Transcription factors with Perturb-seq knockdown data for FURIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FURIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FURIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:90,301,063–90,301,545 | 570.8 kb | Distal (>10kb) Multiome HiCAR | 241 | |
| chr15:90,716,853–90,717,827 | 154.9 kb | Distal (>10kb) Multiome HiCAR | 824 | |
| chr15:90,839,491–90,840,162 | 32.4 kb | Distal (>10kb) Multiome | 261 | |
| chr15:90,869,250–90,869,412 | 2.8 kb | Proximal (<10kb) | 191 | |
| chr15:90,869,617–90,870,019 | 2.1 kb | Proximal (<10kb) | 456 | |
| chr15:90,871,060–90,871,416 | 752 bp | At TSS | 355 | |
| chr15:90,871,720–90,872,555 | at TSS | At TSS | 384 | |
| chr15:90,873,951–90,874,454 | 1.8 kb | Proximal (<10kb) | 647 | |
| chr15:90,883,883–90,884,953 | 12.3 kb | Distal (>10kb) Multiome | 304 | |
| chr15:90,902,271–90,903,624 | 30.5 kb | Distal (>10kb) Multiome | 817 | |
| chr15:90,931,729–90,933,077 | 59.8 kb | Distal (>10kb) Multiome | 926 | |
| chr15:90,934,164–90,935,936 | 63.1 kb | Distal (>10kb) Multiome | 701 | |
| chr15:90,954,493–90,955,641 | 82.8 kb | Distal (>10kb) Multiome | 974 | |
| chr15:90,956,070–90,957,754 | 84.6 kb | Distal (>10kb) Multiome | 410 | |
| chr15:90,994,023–90,995,142 | 122.5 kb | Distal (>10kb) Multiome | 929 | |
| chr15:91,021,873–91,022,829 | 150.4 kb | Distal (>10kb) Multiome | 735 | |
| chr15:91,032,872–91,033,463 | 161.1 kb | Distal (>10kb) Multiome | 347 | |
| chr15:91,099,400–91,100,613 | 228.0 kb | Distal (>10kb) Multiome | 351 | |
| chr15:91,101,202–91,101,847 | 229.4 kb | Distal (>10kb) Multiome | 48 | |
| chr15:91,140,477–91,140,966 | 268.6 kb | Distal (>10kb) Multiome | 31 |
Genomic view of the FURIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.